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The posterior hypothalamus is responsible for the increase of brain temperature during paradoxical sleep

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Summary

Electroencephalogram, caudate nucleus temperature (Tc), ear skin temperature (Te) as well as cerebral blood flow (CBF) measured by a thermal clearance method, were recorded simultaneously and continuously in cats. After baseline recording in which we confirmed the increase of Tc during paradoxical sleep (PS), neuronal cell bodies of the mesencephalic reticular formation and/or the posterior hypothalamus (PH) were destroyed with ibotenic acid. Only PH lesions were followed by either a suppression of the increase or even a decrease of Tc during PS while Te variations were not modified. The decrease in CBF, which was always associated with Tc increase, was suppressed after the PH lesion. These results led us to the conclusion that the increase of Tc at the onset of PS is due to a decrease in CBF. Furthermore, it may be hypothetized that the decrease in CBF depend upon an active vasoconstriction process originating in the PH.

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Authors and Affiliations

  1. Département de Médecine Expérimentale, INSERM U 52, CNRS-UA 1195, Université Claude Bernard, 8 Avenue Rockefeller, F-69373, Lyon Cedex 08, France

    M. Denoyer, M. Sallanon, C. Buda & M. Jouvet

  2. Laboratoire de Thermorégulation et d'Energétique de l'Exercice, CNRS-UA 1341, 8 Avenue Rockefeller, F-69373, Lyon Cedex 08, France

    G. Delhomme & A. Dittmar

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  1. M. Denoyer
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  2. M. Sallanon
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  3. C. Buda
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  4. G. Delhomme
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  5. A. Dittmar
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  6. M. Jouvet
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Denoyer, M., Sallanon, M., Buda, C. et al. The posterior hypothalamus is responsible for the increase of brain temperature during paradoxical sleep. Exp Brain Res 84, 326–334 (1991). https://doi.org/10.1007/BF00231453

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  • DOI: https://doi.org/10.1007/BF00231453

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