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Saccade-related Purkinje cells in the cerebellar hemispheres of the monkey

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Summary

Extracellular single unit discharges of cerebellar Purkinje cells (P-cells) were recorded from the cerebellar hemispheres of two Japanese monkeys (Macaca fuscata) during spontaneous and visually guided eye movements. We found that saccade-related P-cells, whose simple-spike (SS) discharge rates were modulated in close correlation with saccadic eye movements, were localized in fairly restricted areas in the hemisphere, mostly in Crus IIa with some in the deep folia of Crus I. P-cells located in simple lobules, superficial folia of Crus I or in Crus IIp did not change their discharge rate during voluntary eye movements. Fifty-five saccade-related P-cells recorded from Crus I and II showed modulation of SS discharge rate related to both spontaneous and visually triggered saccades, with the modulation closely time-locked to the saccades. Two thirds (37/55) of saccade-related P-cells began to change their SS discharge rate 20–100 ms prior to the onset of saccades. The remaining one third (18/55) changed their activity approximately at the same time as the saccade onset. These saccade-related P-cells did not show changes in activity during smooth pursuit eye movements, and we did not find any P-cells in the cerebellar hemisphere which showed changes of activity preferentially during smooth pursuit eye movements. In about half (26/55) of the saccade-related P-cells, the pattern of modulation prior to and during saccades was biphasic: increase-decrease or decrease-increase. The other half (29/55) showed monophasic increases or decreases. For a given P-cell, the discharge pattern during saccades was similar for saccades of all directions, though there was a preferred direction in the amount of discharge rate modulation. The present findings suggest that the cerebellar hemisphere (Crus I and IIa) plays an important role in the control of voluntary saccadic eye movements, in addition to other cerebellar cortical areas (flocculus and posterior vermis) which are known to participate in the control of saccades.

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References

  • Aschoff JC, Cohen B (1971) Changes in saccadic eye movements produced by cerebellar cortical lesions. Exp Neurol 32:123–133

    Google Scholar 

  • Büttner U, Waespe W (1984) Purkinje cell activity in the primate flocculus during optokinetic stimulation, smooth pursuit eye movements and VOR-suppression. Exp Brain Res 55:97–104

    Google Scholar 

  • Chubb MC, Fuchs AF (1982) Contribution of y group of vestibular nuclei and dentate nucleus of cerebellum to generation of vertical smooth eye movements. J Neurophysiol 48:75–99

    Google Scholar 

  • Fuchs AF, Luschei ES (1970) Firing patterns of abducens neurons of alert monkeys in relationship to horizontal eye movement. J Neurophysiol 33:382–392

    Google Scholar 

  • Fuchs AF, Robinson DA (1966) A method for measuring horizontal and vertical eye movement chronically in the monkey. J Appl Physiol 21:1068–1070

    Google Scholar 

  • Gardner EP, Fuchs AF (1975) Single-unit responses to natural vestibular stimuli and eye movements in deep cerebellar nuclei of the alert rhesus monkey. J Neurophysiol 38:627–649

    Google Scholar 

  • Hamada I, DeLong MR, Mano N (1990) Activity of wrist-related pallidal neurons during fast and slow wrist movements in the monkey. J Neurophysiol 64:1892–1906

    Google Scholar 

  • Hepp K, Henn V, Jaeger J (1982) Eye movement related neurons in the cerebellar nuclei of the alert monkey. Exp Brain Res 45:253–264

    Google Scholar 

  • Kase M, Miller DC, Noda H (1980) Discharges of Purkinje cells and mossy fibers in the cerebellar vermis of the monkey during saccadic eye movements and fixation. J Physiol 300:539–555

    Google Scholar 

  • Lisberger SG, Fuchs AF (1978) Role of primate flocculus during rapid behavioral modification of vestibuloocular reflex. I. Purkinje cell activity during visually guided horizontal smooth-pursuit eye movements and passive head rotation. J Neurophysiol 41:733–763

    Google Scholar 

  • Llinás R, Wolfe JW (1977) Functional linkage between the electrical activity in the vermal cerebellar cortex and saccadic eye movements. Exp Brain Res 29:1–14

    Google Scholar 

  • Madigan JC, Jr, Carpenter MB (1971) Cerebellum of the rhesus monkey: atlas of lobules, laminae, and folia, in sections. Univ Park Press, Baltimore New York Tokyo

    Google Scholar 

  • Mano N, Ito Y, Shibutani H (1990) Localization of saccade-related Purkinje cells in cerebellar hemispheres of the monkey. Jpn J Physiol 40:8204

    Google Scholar 

  • Mano N, Kanazawa I, Yamamoto K (1986) Complex-spike activity of cerebellar Purkinje cells related to wrist tracking movement in the monkey. J Neurophysiol 56:137–158

    Google Scholar 

  • Mano N, Kanazawa I, Yamamoto K (1989) Voluntary movements and complex-spike discharges of cerebellar Purkinje cells. Exp Brain Res Series 17:265–280

    Google Scholar 

  • Mano N, Yamamoto K (1980) Simple-spike activity of cerebellar Purkinje cells related to visually guided wrist tracking movements in the monkey. J Neurophysiol 43:713–728

    Google Scholar 

  • McElligott JG, Keller EL (1982) Neuronal discharge in the posterior cerebellum: its relationship to saccadic eye movement generation. In: Lennerstrand G, Zee DS, Keller EL (ed) Functional basis of ocular motility disorders. Pergamon Press, Oxford, Wenner-Gren Symp Series 37:453–461

  • McElligott JG, Keller EL (1984) Cerebellar vermis involvement in monkey saccadic eye movements: microstimulation. Exp Neurol 86:543–558

    Google Scholar 

  • Meyer-Lohmann J, Hore J, Brooks VB (1977) Cerebellar participation in generation of prompt arm movements. J Neurophysiol 40:1038–1050

    Google Scholar 

  • Miles FA, Braitman DJ, Dow BW (1980) Long-term adaptive changes in primate vestibulo-ocular reflex. IV. Electrophysiological observations in flocculus of adapted monkeys. J Neurophysiol 43:1477–1493

    Google Scholar 

  • Miles FA, Fuller JH (1975) Visual tracking and the primate flocculus. Science 189:1000–1002

    Google Scholar 

  • Noda H, Asoh R, Shibazaki M (1977) Floccular unit activity associated with eye movements and fixation Dev Neurosci 1:371–380

    Google Scholar 

  • Noda H, Mikami A (1986) Discharges of neurons in the dorsal paraflocculus of monkeys during eye movements and visual stimulation. J Neurophysiol 56:1129–1146

    Google Scholar 

  • Noda H, Suzuki DA (1979a) The role of the flocculus of the monkey in saccadic eye movements. J Physiol 294:317–334

    Google Scholar 

  • Noda H, Suzuki DA (1979b) Processing of eye movement signals in the flocculus of the monkey. J Physiol 294:349–364

    Google Scholar 

  • Noda H, Suzuki DA (1979c) The role of the flocculus of the monkey in fixation and smooth pursuit eye movements. J Physiol 294:335–348

    Google Scholar 

  • Optican LM, Robinson DA (1980) Cerebellar-dependent adaptive control of primate saccadic system. J Neurophysiol 44:1058–1076

    Google Scholar 

  • Ritchie L (1976) Effects of cerebellar lesions on saccadic eye movements. J Neurophysiol 39:1246–1256

    Google Scholar 

  • Robinson DA (1963) A method of measuring eye movement using a scleral search coil in a magnetic field. IEEE Trans Biomed Electron, BME 40:137–145

    Google Scholar 

  • Robinson DA (1970) Oculomotor unit behavior in the monkey. J Neurophysiol 33:393–404

    Google Scholar 

  • Ron S, Robinson DA (1973) Eye movements evoked by cerebellar stimulation in the alert monkey. J Neurophysiol 36:1004–1022

    Google Scholar 

  • Suzuki H, Azuma M (1976) A glass-insulated “elgiloy” microelectrode for recording unit activity in chronic monkey experiments. Electroenceph Clin Neurophysiol 41:93–95

    Google Scholar 

  • Suzuki DA, Keller EL (1988) The role of the posterior vermis of monkey cerebellum in smooth-pursuit eye movements control. II. Target velocity-related Purkinje cell activity. J Neurophysiol 59:19–40

    Google Scholar 

  • Suzuki DA, Noda H, Kase M (1981) Visual and pursuit eye movement-related activity in posterior vermis of monkey cerebellum. J Neurophysiol 46:1120–1139

    Google Scholar 

  • Thach WT (1975) Timing of activity in cerebellar dentate nucleus and cerebral motor cortex during prompt volitional movement. Brain Res 88:233–241

    Google Scholar 

  • The Physiological Society of Japan (1989) Guiding principles for the care and use of animals in the field of physiological sciences. Jpn J Physiol 39:i-ii

    Google Scholar 

  • Waespe W, Rudinger D, Wolfensberger M (1985) Purkinje cell activity in the flocculus of vestibular neurectomized and normal monkeys during optokinetic nystagmus (OKN) and smooth pursuit eye movements. Exp Brain Res 60:243–262

    Google Scholar 

  • Westheimer G, Blair SM (1973) Oculomotor defects in cerebellectomized monkeys. Invest Ophthalmol 12:618–621

    Google Scholar 

  • Westheimer G, Blair SM (1974) Functional organization of primate oculomotor system revealed by cerebellectomy. Exp Brain Res 21:463–472

    Google Scholar 

  • Wurtz RH (1969) Response of striate cortex neurons to stimuli during rapid eye movements in the monkey. J Neurophysiol 32:975–986

    Google Scholar 

  • Wurtz RH, Goldberg ME (1972) Activity of superior colliculus in behaving monkey. III. Cells discharging before eye movements. J Neurophysiol 35:575–586

    CAS  PubMed  Google Scholar 

  • Zee DS, Yamazaki A, Butler PH, Gücer G (1981) Effects of ablation of flocculus and paraflocculus on eye movements in primate. J Neurophysiol 46:878–899

    Google Scholar 

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Authors and Affiliations

  1. Department of Neurophysiology, Tokyo Metropolitan Institute for Neurosciences, Musashidai 2-6, Fuchu-shi, 183, Tokyo, Japan

    N. Mano, Y. Ito & H. Shibutani

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  1. N. Mano
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  2. Y. Ito
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  3. H. Shibutani
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Mano, N., Ito, Y. & Shibutani, H. Saccade-related Purkinje cells in the cerebellar hemispheres of the monkey. Exp Brain Res 84, 465–470 (1991). https://doi.org/10.1007/BF00230957

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  • DOI: https://doi.org/10.1007/BF00230957

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