Abstract
Purkinje cells (PCs), the sole output neuron of the cerebellar cortex, are inhibitory projection neurons targeting the cerebellar and vestibular nuclei. They compute excitatory information from granule cells (GCs) and climbing fibers (CFs), and inhibitory information from molecular interneurons (MLIs). PCs display two distinct types of the action potential, the simple spike (SS), which is a regular action potential elicited spontaneously and modulated by GCs, and the complex spike (CS), which is generated by the climbing fiber input. PC dysfunctions lead to the motor as well as non-motor cerebellar disorders.
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Rossi, T., Isope, P. (2023). Purkinje Cells. In: Gruol, D.L., Koibuchi, N., Manto, M., Molinari, M., Schmahmann, J.D., Shen, Y. (eds) Essentials of Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-15070-8_22
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