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Antigen specific T cell factors

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Summary

Antigen specific helper and suppressor factors have a similar structure, with two major sections, a ‘variable region’, determining antigen specificity which is likely to be controlled by Immunoglobulin VH genes, with which it shares idiotype and framework determinants. Specific factors also have a ‘constant region’ which does not vary between strains and minimally between species or with the antigenic specificity of the factors, which are defined by rabbit anti-helper or anti-suppressor antisera. This region determines the biological function of the molecule. Anti-Ia antisera react with factors, but the nature and function of la molecules on T cell factors is still unclear. The model of specific factor structure, with C and V regions resembles that of immunoglobulin, and it is thus possible that the C region of factors, like the V region is Ig linked. Because there are multiple T cells, helping and suppressing antibody responses specifically, it seems improbable that all of these cell could interact directly with, rare antigen-specific B cells. Thus we propose that macrophage presenting cells are the key to the integration of signals for immune induction and regulation for T and B cells. Since Ir genes have been identified in the macrophage presenting cells interacting with both T and B cells, this suggests that macrophage Ia antigens are of importance in the integration of triggering signals for the lymphoid pool.

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Authors and Affiliations

  1. Department of Zoology, Uiversity College, Gower Street, WCIE 6BT, London, England

    Marc Feldmann & Sirkka Kontiainen

  2. Department of Bacteriology and Immunology and Immunology, University of Helsinki, Haartmaninkatu 3, 00290, Helsinki 29, Finland

    Sirkka Kontiainen

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  1. Marc Feldmann
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  2. Sirkka Kontiainen
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Feldmann, M., Kontiainen, S. Antigen specific T cell factors. Mol Cell Biochem 30, 177–193 (1980). https://doi.org/10.1007/BF00230172

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