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Connexon rearrangement in cardiac gap junctions: Evidence for cytoskeletal control?

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Summary

Using ultrarapid-freezing techniques and freezefracture electron microscopy, we report here a close association between cardiac gap junctions and specialized membrane domains containing regularly-spaced furrows. These specialized furrowed domains are observed only during periods of gap junction re-organisation (i.e., connexon redistribution) and may reflect the presence of underlying cytoskeletal elements controlling the position of connexons in the membrane.

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Author notes

  1. N. J. Severs

    Present address: Department of Cardiac Medicine, Cardiothoracic Institute, University of London, 2, Beaumont Street, W1N 2DX, London, UK

Authors and Affiliations

  1. Department of Cardiac Medicine, Cardiothoracic Institute, University of London, London, UK

    C. R. Green &  N. J. Severs

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  1. C. R. Green
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  2. N. J. Severs
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Green, C.R., Severs, N.J. Connexon rearrangement in cardiac gap junctions: Evidence for cytoskeletal control?. Cell Tissue Res. 237, 185–186 (1984). https://doi.org/10.1007/BF00229215

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  • DOI: https://doi.org/10.1007/BF00229215

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