Abstract
The present study shows that systemic administration of the selective, non-competitive N-methyl-d-aspartate antagonist MK-801 [(+)-5-methyl-10,11-dihydroxy-5H-dibenzo(a,d)-cyclohepten-5,10-imine] dose-dependently induces ipsiversive rotational behavior in the rats with a unilateral striatal lesion produced by transient middle cerebral artery occlusion or in those with a unilateral nigrostriatal lesion produced by 6-hydroxydopamaine. In relation to a functional model of the basal ganglia-thalamocortical ‘motor’ circuit, the present data suggest that the striatum may be one of the most important sites where MK-801 acts in the basal ganglia, with its being responsible for the circling behavior of the animal models.
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Supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan
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Goto, S., Korematsu, K., Inoue, N. et al. N-Methyl-d-aspartate receptor antagonist MK-801 induced circling behavior in rats with unilateral striatal ischemic lesions or nigral 6-hydroxydopamine lesions. Acta Neuropathol 86, 480–483 (1993). https://doi.org/10.1007/BF00228583
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DOI: https://doi.org/10.1007/BF00228583