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Inositolpolyphosphates and their binding proteins —a short review

  • Part IV: Cardiovascular Therapeutics
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Abstract

Since 1983, when it was discovered that inositol 1,4,5-trisphosphate can act as second messenger to release Ca2+ from the endoplasmic reticulum, widespread research has focused on the phosphatidylinositol signalling transduction pathway and the host of inositolphosphates formed intracellularly after stimulation thereof. Although the polyphosphates, inositoltetrakisphosphate (InsP4) and inositolhexakisphosphate (InsP6), have received their share of attention, a definite physiological role has not been ascribed to them as yet. Different binding proteins for these two polyphosphates have been demonstrated, especially in brain tissue, indicating their possible importance in the cell.

InsP6 is known as one of nature's most powerful antioxidants and has already been demonstrated to possess the abilities to be of use in the industry as well as in the medical profession. As its natural actions are poorly understood and its possible side-effects have not been widely investigated, basic research regarding its cellular and subcellular activities is urgently called for.

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Authors and Affiliations

  1. Department of Medical Physiology and Biochemistry, Faculty of Medicine, University of Stellenbosch, Tygerberg, Republic of South Africa

    Barbara Huisamen & Amanda Lochner

  2. MRC Programme for Experimental Biology, Tygerberg, Republic of South Africa

    Barbara Huisamen & Amanda Lochner

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  1. Barbara Huisamen
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  2. Amanda Lochner
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Recipient of Servier Investigator Award

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Huisamen, B., Lochner, A. Inositolpolyphosphates and their binding proteins —a short review. Mol Cell Biochem 157, 229–232 (1996). https://doi.org/10.1007/BF00227903

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