Summary
This immunocytochemical study describes the presence of separate immunoreactive (IR)-urotensin II (UII) and IR-somatostatin (SOM) systems in the spinal cord of two species of teleost fish. Both systems are arranged in a close spatial interrelationship in which IR-SOM fibres apparently innervate cerebrospinal fluid (CSF)-contacting IR-UII neurons. Specimens of Oncorhynchus kisutch also display CSF-contacting IR-SOM neurons located in the lateral ependymal walls of the central canal, in addition to CSF-contacting IR-UII neurons located ventrally. It is suggested that, in this species, CSF-contacting IR-SOM and IR-UII neurons perceive different stimuli from the CSF and are integrated in such a way that one peptidergic system may modulate the function of the other.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Burnweit C, Forssmann WG (1979) Somatostatinergic nerves of the cervical spinal cord of the monkey. Cell Tissue Res 200:83–90
Dalsgaard CJ, Hökfelt T, Johansson O, Elde R (1981) Somatostatin immunoreactive cell bodies in the dorsal horn and the parasympathetic intermediolateral nucleus of the rat spinal cord. Neurosci Lett 27:335–339
Desy L, Pelletier G (1977) Immunohistochemical localization of somatostatin in the human hypothalamus. Cell Tissue Res 184:491–497
Dubois MP, Billard R, Breton B, Peter RE (1979) Comparative distribution of somatostatin, LH-RH, neurophysin, and alpha-endorphin in the rainbow trout: An immunocytological study. Gen Comp Endocrinol 37:220–232
Forssmann WG, Burnweit C, Shehab T, Triepel J (1979) Somatostatin-immunoreactive nerve cell bodies and fibres in the medulla oblongata et spinalis. J Histochem Cytochem 27:1391–1393
Ho RH (1983) Widespread distribution of substance P- and somatostatin-immunoreactive elements in the spinal cord of the neonatal rat. Cell Tissue Res 232:471–486
Ichikawa T, Lederis K, Kobayashi H (1983) Primary structures of multiple forms of urotensin II in the urophysis of the carp, Cyprinus carpio. Gen Comp Endocrinol 55:133–141
Johansson O, Hökfelt T, Elde RP (1984) Immunohistochemical distribution of somatostatin-like immunoreactivity in the central nervous system of the adult rat. Neuroscience 13:265–339
King JA, Millar RP (1979) Phylogenetic and anatomical distribution of somatostatin in vertebrates. Endocrinology 105:1322
Kobayashi Y, Lederis K, Rivier J, Ko D, McMaster D, Poulin P (1986) Radioimmunoassays for fish tail neuropeptides: II. Development of a specific and sensitive assay for and the occurrence of immunoreactive urotensin II in the central nervous system and blood of Castostomus commersoni. J Pharmacol Methods 15:321–333
Krukoff TL, Ciriello J, Calaresu FR (1986) Somatostatin-like immunoreactivity in neurons, nerve terminals, and fibres of the cat spinal cord. J Comp Neurol 243:13–22
McMaster D, Lederis K (1983) Isolation and amino acid sequence of two urotensin II peptides from Catostomus urophysis. Peptides 3:367–373
Olivereau M, Ollevier F, Vandesande F, Olivereau J (1984a) Somatostatin in the brain and the pituitary of some teleosts: Immuno cytochemical identification and the effect of starvation. Cell Tissue Res 238:289–296
Olivereau M, Ollevier F, Vandesande F, Verdonck W (1984b) Immunocytochemical identification of CRF-like and SRIF-like peptides in the brain and the pituitary of cyprinid fish. Cell Tissue Res 237:379–382
Onstott D, Elde R (1986a) Coexistence of urotensin I/corticotropin-releasing factor and urotensin II immunoreactivities in cells of the caudal neurosecretory system of a teleost and an elasmobranch fish. Gen Comp Endocrinol 63:295–300
Onstott D, Elde R (1986b) Immunohistochemical localization of urotensin I/corticotropin-releasing factor, urotensin II, and serotonin immunoreactivities in the caudal spinal cord of nonteleost fishes. J Comp Neurol 249:205–225
Owada K, Kawata M, Akaji K, Takagi A, Moriga M, Kobayashi H (1985a) Urotensin II-immunoreactive neurons in the caudal neurosecretory system of freshwater and seawater fish. Cell Tissue Res 239:349–354
Owada K, Yamada C, Kobayashi H (1985b) Immunohistochemical investigation of urotensins in the caudal spinal cord of four species of elasmobranchs and the lamprey, Lampetra japonica. Cell Tissue Res 242:527–530
Pearson D, Shively JE, Clark BR, Geschwind II, Barkley M, Nishioka RS, Bern HA (1980) Urotensin II: A somatostatinlike peptide in the caudal neurosecretory system of fishes. Proc Natl Acad Sci USA 77:5021–5024
Schroder HD (1984) Somatostatin in the caudal spinal cord: An immunohistochemical study of the spinal centres involved in the innervation of pelvic organs. J Comp Neurol 223:400–414
Senba E, Shiosaka S, Hara Y, Inagaki S, Sakanaka M, Takatsuki K, Kawai Y, Tohyama M (1982) Ontogeny of the peptidergic system in the rat spinal cord: Immunohistochemical analysis. J Comp Neurol 208:54–66
Sternberger LA, Hardy PH, Cuculis JJ, Meyer HG (1970) The unlabeled antibody enzyme method of immunohistochemistry: Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase-antiperoxidase) and its use in identification of spirochetes. J Histochem Cytochem 18:315–333
Vale W, Ling N, Rivier J, Villarreal J, Rivier C, Douglas C, Brown M (1976) Anatomic and phylogenetic distribution of somatostatin. Metabolism 25:1491–1494
Vigh-Teichmann I, Vigh B, Korf H-W, Oksche A (1983) CSFcontacting and other somatostatin-immunoreactive neurons in the brains of Anguilla anguilla, Phoxinus phoxinus, and Salmo gairdneri (Teleostei). Cell Tissue Res 233:319–334
Yamada C, Owada K, Kobayashi H (1985) Colocalization of corticotropin-releasing factor/urotensin I and urotensin II in the caudal neurosecretory neurons in the carp, Cyprinus carpio. Zool Science 2:813–816
Yulis CR, Lederis K (1986) Extraurophyseal distribution of urotensin II immunoreactive neuronal perikarya and their processes. Proc Natl Acad Sci USA 83:7079–7084
Yulis CR, Lederis K (1988) Occurrence of an anterior spinal, CSF-contacting, urotensin II neuronal system in different fish species. Gen Comp Endocrinol 70:301–311
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yulis, C.R., Lederis, K. Relationship between urotensin II- and somatostatin-immunoreactive spinal cord neurons of Catostomus commersoni and Oncorhynchus kisutch (Teleostei). Cell Tissue Res. 254, 539–542 (1988). https://doi.org/10.1007/BF00226503
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00226503