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Concerning the decreased D-3-hydroxybutyrate dehydrogenase activity in the liver and heart of hyperthyroid rats

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Summary

Whereas in rat liver mitochondria the hyperthyroid state causes an increase both in fatty acid unsaturation and in the Ea of D-3-hydroxybutyrate dehydrogenase and a decrease in phase transition temperature, in hyperthyroid rat heart mitochondria these changes are negligible. D-3-hydroxybutyrate dehydrogenase in both the liver and the heart mitochondria of hyperthyroid rats is reduced by about 35% [l2] but this reduction is not due to changes in membrane fluidity in either tissue. Hypothyroidism, on the other hand, affects BDH activity in neither heart nor liver.

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Abbreviations

BDH:

D-3-hydroxybutyrate dehydrogenase

PTU:

6n-propyl-2-thiouracil

T3,3,3′:

5-L-triiodothyronine

Tm:

temperature phase transition

Ea:

apparent activation energy

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Author notes

  1. Paola Morini, Elisabetta Casalino & Elemente Landriscina

    Present address: Institute of Chemistry, Laboratory of Biochemistry, Faculty of Veterinary Medicine, University of Bari, Via Gentile 182, 70126, Bari, Italy

Authors and Affiliations

  1. Research Unit on Mitochondria and Energy Metabolism, National Research Council, Via Amendola 165/A, 70126, Bari, Italy

    Rosa Lippolis, Paola Morini, Anna Rosa Conserva, Elisabetta Casalino & Elemente Landriscina

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  1. Rosa Lippolis
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Lippolis, R., Morini, P., Conserva, A.R. et al. Concerning the decreased D-3-hydroxybutyrate dehydrogenase activity in the liver and heart of hyperthyroid rats. Mol Cell Biochem 93, 147–152 (1990). https://doi.org/10.1007/BF00226186

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  • DOI: https://doi.org/10.1007/BF00226186

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