Skip to main content
SpringerLink
Log in

Growth regulation by nerve growth factor

  • Review Articles
  • Published:
Molecular and Cellular Biochemistry Aims and scope Submit manuscript

Summary

Although a great deal of descriptive information has been obtained about the actions of nerve growth factor on its target tissues, its structure, its receptors, and even its biosynthesis, there is no clear understanding, as yet, of the intracellular events mediating its transcriptional involvements. Work in this laboratory over the past five years has uncovered a number of nerve growth factor-initiated intracellular changes in sympathetic neurons and other nerve growth factor-sensitive systems, and has provided a framework into which they might fit. This article is written in an attempt to collect the data in a single communication and to suggest at least one mechanism by which the nerve growth factor may work

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Levi-Montalcini, R., 1966. Harvey Lect. 60, 217–259.

    Google Scholar 

  2. Levi-Montalcini, R. and Angeletti, P. U., 1968. Physiol. Rev. 48, 534–569.

    Google Scholar 

  3. Bueker, E. D., 1948. Anat. Record. 102, 369–390.

    Google Scholar 

  4. Bueker, E. D., 1948. Anat. Record. 100, 735.

    Google Scholar 

  5. Levi-Montalcini, R. and Hamburger, V., 1951. J. Exptl. Zool. 116, 321–362.

    Google Scholar 

  6. Levi-Montalcini, R. and Hamburger, V., 1953. J. Exptl. Zool. 123, 233–288.

    Google Scholar 

  7. Levi-Montalcini, R., Meyer, H. and Hamburger, V., 1954. Cancer Res. 14, 49–57.

    Google Scholar 

  8. Cohen, S., 1959. J. Biol. Chem. 234, 1129–1137.

    Google Scholar 

  9. Cohen, S., 1960. Proc. Natn. Acad. Sci., U.S.A. 46, 302–311.

    Google Scholar 

  10. Levi-Montalcini, R. and Booker, B., 1960. Proc. Natn. Acad. Sci., U.S.A. 46, 384–391.

    Google Scholar 

  11. Bocchini, V. and Angeletti, P. U., 1969. Proc. Natn. Acad. Sci., U.S.A. 64, 787–794.

    Google Scholar 

  12. Varon, S., Nomura, J. and Shooter, E. M., 1967. Biochem. 6, 2202–2209.

    Google Scholar 

  13. Varon, S., Nomura, J. and Shooter, E. M., 1967. Proc. Natn. Acad. Sci., U.S.A. 57, 1782–1789.

    Google Scholar 

  14. Mobley, W. C., Schenker, A. and Shooter, E. M., 1976. Biochem. 15, 5543–5552.

    Google Scholar 

  15. Pattison, S. E. and Dunn, M. F., 1975. Biochem. 14, 2733–2739.

    Google Scholar 

  16. Burton, L. E., Wilson, W. H. and Shooter, E. M., 1978. J. Biol. Chem. 253, 7807–7812.

    Google Scholar 

  17. Angeletti, R. H. and Bradshaw, R. A., 1971. Proc. Natn. Acad. Sci., U.S.A. 68, 2417–2420.

    Google Scholar 

  18. Frazier, W. A., Angeletti, R. H. and Bradshaw, R. A., 1972. Science 176, 482–488.

    Google Scholar 

  19. Frazier, W. A., Angeletti, R. H., Sherman, R. and Bradshaw, R. A., 1973. Biochem. 12, 3281–3293.

    Google Scholar 

  20. Argos, P., 1976. Biochem. Biophys. Res. Comm. 70, 805–811.

    Google Scholar 

  21. Greene, L. A., 1974. Neurobiol. 4, 286–292.

    Google Scholar 

  22. Johnson, D. G., Gorden, P. and Kopin, I. J., 1971. J. Neurochem. 18, 2355–2362.

    Google Scholar 

  23. Hendry, I. A., 1972. Biochem. J. 128, 1265–1272.

    Google Scholar 

  24. Angeletti, P. and Vigneti, E., 1971. Brain Res. 33, 601–604.

    Google Scholar 

  25. Oger, J., Arnason, B. G. W., Pantazis, N., Lehrich, J. and Young, M., 1974. Proc. Natn. Acad. Sci., U.S.A. 71,1554–1558.

    Google Scholar 

  26. Shine, H. D. and Perez-Polo, J. R., 1976. J. Neurochem. 26, 513–519.

    Google Scholar 

  27. Perez-Polo, J. R., Blum, M. A. and Beck, C. E., 1978. Trans. Am. Soc. Neurochem. 9, 148.

    Google Scholar 

  28. Suda, K., Barde, A. and Thoenen, H., 1978. Proc. Nam. Acad. Sci., U.S.A. 75, 4042–4046.

    Google Scholar 

  29. Tomita, J. T. and Varon, S. 1971. Neurobiol. 1, 176–190.

    Google Scholar 

  30. Stoeckel, K., Gagnon, C., Guroff, G. and Thoenen, H., 1976. J. Neurochem. 26, 1207–1211.

    Google Scholar 

  31. Young, M., Oger, T., Blanchard, M. H., Asdourian, H., Amos, H. and Arnason, B. G. W., 1975. Science 187,361–362.

    Google Scholar 

  32. Murphy, R. A., Pantazis, N. T., Arnason, B. G. W. and Young, M., 1975. Proc. Natn. Acad. Sci., U.S.A. 72,1895–1898.

    Google Scholar 

  33. Arnason, B. G. W., Oger, J., Pantazis, N. J. and Young, M., 1974. J. Clin. Invest. 53, 2a.

    Google Scholar 

  34. Saide, J. D., Murphy, R. A., Canfield, R. E., Skinner, J., Robinson, D. B., Amason, B. G. W. and Young, M., 1975. J. Cell Biol. 67, 376a.

  35. Schwartz, J. P., Chuang, D. and Costa, E., 1977. Brain Res. 137, 369–375.

    Google Scholar 

  36. Perez-Polo, J. R., Hall, K., Livingston, K. and Westlund, K., 1977. Life Sci. 21, 1535–1544.

    Google Scholar 

  37. Berger, E. A. and Shooter, E. M., 1978. J. Biol. Chem. 253, 804–810.

    Google Scholar 

  38. Burton, L. E., Wilson, W. H. and Shooter, E. M., 1978. J. Biol. Chem. 253, 7807–7812.

    Google Scholar 

  39. Aloe, L. and Levi-Montalcini, R., 1979. Proc. Natn. Acad. Sci., U.S.A. 76, 1246–1250.

    Google Scholar 

  40. Unsicker, K., Krisch, B., Otten, U. and Thoenen, H., 1978. Proc. Natn. Acad. Sci., U.S.A. 75, 3498–3502.

    Google Scholar 

  41. Otten, U., Schwab, M., Gagnon, C. and Thoenen, H., Brain Res. 133, 291–303.

  42. Merrel, R., Pulliam, M. W., Randono, L., Boyd, L. F., Bradshaw, R. A. and Glaser, L., 1975. Proc. Natn. Acad. Sci., U.S.A. 72, 4270–4274.

    Google Scholar 

  43. Eisenbarth, G. S., Drezner, M. K. and Lebovitz, H. E., 1975. J. Pharm. Exp. Ther. 192, 630–634.

    Google Scholar 

  44. Björklund, A. and Stenevi, U., 1972. Science 175, 1251–1253.

    Google Scholar 

  45. Stenevi, U., Bjerre, B., Björklund, A. and Mobley, W., 1974. Brain Res. 69, 217–234.

    Google Scholar 

  46. Bjerre, B., Björklund, A. and Stenevi, U., 1973. Brain Res. 60, 161–176.

    Google Scholar 

  47. Greene, L. A. and Tischler, A. S., 1976. Proc. Natn. Acad. Sci., U.S.A. 73, 2424–2428.

    Google Scholar 

  48. Greene, L. A. and Rein, G., 1977. Brain Res. 129, 247–263.

    Google Scholar 

  49. Dichter, M. A., Tischler, A. S. and Greene, L. A., 1977. Nature 258, 501–504.

    Google Scholar 

  50. Goodman, R. and Herschman, H., 1978. Proc. Natn. Acad. Sci., U.S.A. 75, 4587–4590.

    Google Scholar 

  51. Fabricant, R. F., DeLarco, J. E. and Todaro, G. J., 1977. Proc. Natn. Acad. Sci., U.S.A. 74, 565–569.

    Google Scholar 

  52. Revoltella, R., Bertolini, L., Pediconi, M. and Vigneti, E., 1974. J. Exp. Med. 140, 437–451.

    Google Scholar 

  53. Reynolds, C. P. and Perez-Polo, J. R., 1975. Neurosci. Lett. 1, 91–97.

    Google Scholar 

  54. Banerjee, S. P., Snyder, S. H., Cuatrecasas, P. and Greene, L. A. 1973. Proc. Natn. Acad. Sci., U.S.A. 70,2519–2523.

    Google Scholar 

  55. Herrup, K. and Shooter, E. M., 1973. Proc. Natn. Acad. Sci., U.S.A. 70, 3884–3888.

    Google Scholar 

  56. Frazier, W. A., Boyd, L. F. and Bradshaw, R. A., 1974. J. Biol. Chem. 249, 5513–5519.

    Google Scholar 

  57. Hendry, I. A., Stöckel, K., Thoenen, H. and Iversen, L. L., 1974. Brain Res. 68, 103–121.

    Google Scholar 

  58. Stöckel, K., Paravicini, U. and Thoenen, H., 1974. Brain Res. 76, 413–421.

    Google Scholar 

  59. Stöckel, K., Guroff, G., Schwab, M. and Thoenen, H., 1976. Brain Res. 109, 271–284.

    Google Scholar 

  60. Andres, R. Y., Jeng, I. and Bradshaw, R. A., 1977. Proc. Natn. Acad. Sci., U.S.A. 74, 2785–2789.

    Google Scholar 

  61. Yankner, B. A. and Shooter, E. M., 1979. Proc. Natn. Acad. Sci., U.S.A. 76, 1269–1273.

    Google Scholar 

  62. Thoenen, H., Angeletti, P. U., Levi-Montalcini, R. and Kettler, R., 1971. Proc. Natn. Acad. Sci., U.S.A. 68, 1598–1602.

    Google Scholar 

  63. Nikodijevic, B., Yu, M. W. and Guroff, G., 1977. J. Neurochem. 28, 851–852.

    Google Scholar 

  64. Yu, M. W., Nikodijevic, B., Lakshmanan, J., Rowe, V., MacDonnell, P. C. and Guroff, G., 1977. J. Neurochem. 28, 835–842.

    Google Scholar 

  65. Nagatsu, T., Levitt, M. and Udenfriend, S., 1964. Anal. Biochem. 9, 122–126.

    Google Scholar 

  66. Oesch, F., Otten, U. and Thoenen, H., 1973. J. Neurochem. 20, 1691–1706.

    Google Scholar 

  67. MacDonnell, P. C., Tolson, N., Yu, M. W. and Guroff, G., 1977. J. Neurochem. 28, 843–849.

    Google Scholar 

  68. MacDonnell, P. C., Tolson, N. and Guroff, G., 1977. J. Biol. Chem. 252, 5859–5863.

    Google Scholar 

  69. Weber, K., Pringle, J. R. and Osborn, M., 1972. Methods in Enzymology, Vol. 26, (Hirs, C. H. W. and Timasheff, S. N., eds.) pp. 3–27.

  70. Nikodijevic, B., Nikodijevic, O., Yu, M. W., Pollard, H. and Guroff, G., 1975. Proc. Natn. Acad. Sci., U.S.A. 72, 4769–4771.

    Google Scholar 

  71. Gilman, A. G., 1970. Proc. Natn. Acad. Sci., U.S.A. 67,305–312.

    Google Scholar 

  72. MacDonnell, P. C., Nagaiah, K., Lakshmanan, J. and Guroff, G., 1977. Proc. Natn. Acad. Sci., U.S.A. 74, 4681–4684.

    Google Scholar 

  73. Lewis, M. E., Lakshmanan, J., Nagaiah, K., MacDonnell, P. C. and Guroff, G., 1978. Proc. Natn. Acad. Sci., U.S.A. 75, 1021–1023.

    Google Scholar 

  74. Nagaiah, K., Ikeno, T., Lakshmanan, J., MacDonnell, P. C. and Guroff, G., 1978. Proc. Natn. Acad. Sci., U.S.A. 75, 2512–2515.

    Google Scholar 

  75. Pegg, D. E. and Williams-Ashman, H. G., 1968. Biochem. J. 108, 533–539.

    Google Scholar 

  76. Oka, T. and Perry, J. W., 1976. J. Biol. Chem. 251, 1738–1744.

    Google Scholar 

  77. Yu, M. W., Hori, S., Tolson, N., Huff, K. and Guroff, G., 1978. Biochem. Biophys. Res. Comm. 81, 941–946.

    Google Scholar 

  78. Panyim, S. and Chalkley, R., 1969. Arch. Biochem. Biophys. 130, 337–346.

    Google Scholar 

  79. Huff, K., Lakshmanan, J. and Guroff, G., 1978. J. Neurochem. 31, 599–606.

    Google Scholar 

  80. Austoker, J., Cox, D. and Mathias, A. P., 1972. Biochem. J. 129, 1139–1155.

    Google Scholar 

  81. Banks, J. P. and Johnson, T. C., 1973. Science 181, 1064–1065.

    Google Scholar 

  82. Huff, K. R. and Guroff, G., 1979. Biochem. Biophys. Res. Comm., 89, 175–180.

    Google Scholar 

  83. Schubert, D. and Whitlock, C., 1977. Proc. Natn. Acad. Sci., U.S.A. 74, 4055–4058.

    Google Scholar 

  84. Savage, C. and Cohen, S., 1972. J. Biol. Chem. 247, 7609–7611.

    Google Scholar 

  85. Cuatrecasas, P., 1971. Proc. Natn. Acad. Sci., U.S.A. 68, 1264–1268.

    Google Scholar 

  86. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J., 1951. J. Biol. Chem. 193, 265–275.

    Google Scholar 

  87. Letendre, C. H., MacDonnell, P. C. and Guroff, G., 1977. Biochem. Biophys. Res. Comm. 74, 891–897 and 76, 615–617.

    Google Scholar 

  88. Hier, D. B., Arnason, B. G. W. and Young, M., 1973. Science 182, 79–81.

    Google Scholar 

  89. Frazier, W. G., Ohlendorf, C. E., Boyd, L. F., Aloe, L., Johnson, E. M., Ferrendelli, J. A. and Bradshaw, R. A., 1973. Proc. Natn. Acad. Sci., U.S.A. 70, 2448–2452.

    Google Scholar 

  90. Guidotti, A., Hanbauer, I. and Costa, E., 1975. In Advances in Cyclic Nucleotide Research, Vol. 5 (G. L. Drummond, P. Greengard and G. A. Robison, eds.) Raven Press, New York, pp. 619–639.

  91. Guidotti, A., Mao, C. C. and Costa, E., 1974. In Advances in Cytopharmacology, Vol. 2 (B. Ceccarelli, F. Clementi and J. Mendolesi, eds) Raven Press, New York, pp. 39–46.

  92. Narumi, S. and Fujita, T., 1978. Neuropharm. 17, 73–76.

    Google Scholar 

  93. Skaper, S. D., Bottenstein, J. E. and Varon, S., 1979. J. Neurochem. 32, 1845–1851.

    Google Scholar 

  94. Otten, U., Hatanaka, H. and Thoenen, H., 1978. Brain Res. 140, 385–389.

    Google Scholar 

  95. Lakshmanan, J., 1978. Brain Res. 157, 173–177.

    Google Scholar 

  96. Byus, C. V. and Russell, D. H., 1974. Life Sci. 15, 1991–1997.

    Google Scholar 

  97. Byus, C. V. and Russell, D. H., 1975. Science 187, 650–652.

    Google Scholar 

  98. Russell, D. H., Byus, C. V. and Manen, C., 1976. Life Sci. 19, 1297–1306.

    Google Scholar 

  99. Ishii, D. N., 1978. Cancer Res. 38, 3887–3893.

    Google Scholar 

  100. Greene, L. A. and McGuire, J. C., 1978. Nature 276, 191–194.

    Google Scholar 

  101. Mcguire, J. C., Greene, L. A. and Furano, A. V., 1978. Cell 15, 357–365.

    Google Scholar 

  102. Cohen, S. and Taylor, J. M., 1974. Recent Progr. Hormone Res. 30, 533–550.

    Google Scholar 

  103. Cohen, S. and Savage, C. R., Jr., 1974. Recent Progr. Hormone Res. 30, 551–574.

    Google Scholar 

  104. Cohen, S., Carpenter, G. and Lembach, K. J., 1975. Adv. Metab. Disord. 8, 265–284.

    Google Scholar 

  105. Berger, B. D., Wise, C. D. and Stein, L., 1973. Science 180, 506–508.

    Google Scholar 

  106. Frazier, W. A., Boyd, L. F., Szutowicz, A., Pulliam, M. W. and Bradshaw, R. A., 1974. Biochem. Biophys. Res. Comm. 57, 1096–1103.

    Google Scholar 

  107. Frazier, W. A., Boyd, L. F., Pulliam, M. W., Szutowicz, A. and Bradshaw, R. A., 1974. J. Biol. Chem. 249, 5918–5923.

    Google Scholar 

  108. Szutowicz, A., Frazier, W. A. and Bradshaw, R. A., 1976. J. Biol. Chem. 251, 1516–1523.

    Google Scholar 

  109. Szutowicz, A., Frazier, W. A. and Bradshaw, R. A., 1976. J. Biol. Chem. 251, 1524–1528.

    Google Scholar 

  110. Walker, P., Weichsel, M. E., Jr., Fisher, D. A., Guo, S. M. and Fisher, D. A., 1979. Science 204, 427–429.

    Google Scholar 

  111. Roger, L. J., Schanberg, S. M. and Fellows, R. E., 1974. Endocrinology 95, 904–911.

    Google Scholar 

  112. Hatanaka, H., Otten, U. and Thoenen, H., 1978. FEBS Lett. 92, 313–316.

    Google Scholar 

  113. Max, S. R., Rohrer, H., Otten, U. and Thoenen, H., 1978. J. Biol. Chem. 253, 8013–8015.

    Google Scholar 

  114. Vinores, S. and Guroff, G., in preparation.

  115. 115. Ikeno, T. and Guroff, G., J. Neurochem., in press.

  116. Perkins, M. S., Margules, D. L. and Ward, I. L., 1979. Brain Res. 161, 531–355.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section on Intermediary Metabolism, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, 20205, Bethesda, Maryland, USA

    Takeyuki Ikeno & Gordon Guroff

Authors
  1. Takeyuki Ikeno
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gordon Guroff
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ikeno, T., Guroff, G. Growth regulation by nerve growth factor. Mol Cell Biochem 28, 67–91 (1979). https://doi.org/10.1007/BF00223360

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00223360

Keywords

Search

Navigation