Summary
Neural lobes from rats subjected to neurohypophysial hormone-releasing stimuli were examined electron microscopically following fixation in 4 % tannic acid in 2.5 % glutaraldehyde. This fixation allowed the delineation of the perivascular space in the neural lobe tissue. Measurement of the area of the perivascular space showed that it was significantly increased in the rats subjected to vagal stimulation and intraarterial calcium ions compared to the control rats. The rats which had been subjected to haemorrhage as a hormonereleasing stimulus did not show any significant change in the area of the perivascular space. The significance of these findings in relation to hormone release is discussed.
Similar content being viewed by others
References
Barer, R., Lederis, K.: Ultrastructure of the rabbit neurohypophysis with special reference to the release of hormones. Z. Zellforsch. 75, 201–239 (1966)
Bodian, D.: Cytological aspects of neurosecretion in opossum neurohypophysis. Bull. Johns Hopk. Hosp. 113, 57–93 (1963)
Brettschneider, H.: Die Feinstruktur des nervösen Parenchyms von Infundibulum und Neurohypophyse. Z. mikr.-anat. Forsch. 64, 575–590 (1958)
Chang, H.C., Chia, K.F., Huang, J.H., Lim, R.K.S.: Vagus post-pituitary reflex antidiuretic effect. Chin. J. Physiol. Rep. Ser. 14, 161–172 (1939)
Douglas, W. W.: How do neurones secrete peptides? Exocytosis and its consequences including ‘synaptic vesicle’ formation in the hypothalamo-neurohypophyseal system. In: Progress in brain research, Vol 39, pp. 21–39. Eds. Zimmerman, E., Gispen, W.H., Marks, B.H., and de Wied, D. Amsterdam: Elsevier 1973
Douglas, W.W., Poisner, A.M.: Stimulus secretion coupling in a neurosecretory organ: the role of calcium in the release of VP from the neurohypophysis. J. Physiol. (Lond.) 172, 1–18 (1964)
Duncan, D.: An electron microscopic study of the neurohypophysis of a bird Callus domesticus. Anat. Rec. 125, 457–471 (1956)
Dyball, R.E.: Stimuli for the release of neurohypophysial hormones. Brit. J. Pharmacol. 33, 319–328 (1968)
Ginsburg, M., Brown, L.M.: Effect of anaesthesia and haemorrhage on the release of neurohypophysial antidiuretic hormone. Brit. J. Pharmacol. 11, 236–244 (1956)
Hartmann, J.F.: Electron microscopy of the neurohypophysis in normal and histamine treated rats. Z. Zellforsch. 48, 291–308 (1958)
Lederis, K.: Neurosecretion and the functional structure of the neurohypophysis. In: Handbook of physiology — Endocrinology IV, Part 1, pp. 81–102. Eds. Knobil, E., Sawyer, W.H. Washington: American Physiological Soc. 1974
Livingston, A.: Morphology of the perivascular regions of the rat neural lobe in relation to hormone release. Cell Tiss. Res. 159, 551–561 (1975)
Livingston, A.: Granule numbers and hormone stores in the rat neurohypophysis during saline dehydration. J. Endocr. 69, 3P (1976)
Livingston, A., Wilks, P.: Perivascular regions of the rat neural lobe. Cell Tiss. Res. 174, 273–280 (1976)
Norström, A.: Subcellular distribution of neurophysin in rats subjected to haemorrhage, salt loading and lactation and in rats with hereditary diabetes insipidus (Brattleboro strain). Z. Zellforsch. 140, 413–424 (1973)
Norström, A.: The heterogeneity of the neurohypophysial pool of neurophysin. In: Neurosecretion —the final neuroendocrine pathway, pp. 86–93. Eds. Knowles, F., Vollrath, L. Berlin-Heidelberg-New York: Springer 1974
Palay, S.L.: The fine structure of the neurohypophysis In: Ultrastructure and cellular chemistry of neural tissue, pp. 31–49. Eds. Waelsch H. New York: Hoeber 1957
Sooriyamoorthy, T., Livingston, A.: Variations in the blood volume of the neural and anterior lobes of the pituitary of the rat associated with neurohypophysial hormone-releasing stimuli. J. Endocr. 54, 407–415 (1972)
Sooriyamoorthy, T., Livingston, A.: Blood flow studies in the neural lobe of the pituitary of the rabbit associated with neurohypophysial hormone-releasing stimuli. J. Endocr. 57, 75–85 (1973)
Swann, R.W., Pickering, B.T.: Incorporation of radioactive precursors into the membrane and contents of the neurosecretory granules of the rat neurohypophysis as a method of studying their fate. J. Endocr. 68, 95–108 (1976)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Livingston, A. Effects of hormone-releasing stimuli on the area of the perivascular space in the neural lobe of the rat. Cell Tissue Res. 191, 501–506 (1978). https://doi.org/10.1007/BF00219812
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00219812