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The chlorpromazine inhibition of transport ATPase and acetylcholinesterase activities in the microsomal membranes of rat in vitro and in vivo

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Abstract

Chlorpromazine, an antipsychotic drug, is found to inhibit Na+,K+-ATPase activity in rat brain microsomal membranes in vitro in concentration and time dependent manner but some inconsistency is observed when the effect was studied with respect to different temperatures. Various ligands and/or substrate affect the inhibition by chlorpromazine in different ways. The in vivo study with this drug shows that the activities of Na+,K+-ATPase, Ca−2-ATPase and acetylcholinesterase in the microsomal membranes of different organs are inhibit with increases in concentration or lengths of time of treatment and then levels off.

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Author notes

  1. Shyamali Mukherjee

    Present address: Department of Biochemistry, Meharry Medical College, School of Medicine, 37209, Nashville, TN, USA

Authors and Affiliations

  1. Department of Chemistry, Bose Institute, 700 009, Calcutta, India

    Barsanjit Mazumder, Shyamali Mukherjee & Parimal C. Sen

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  1. Barsanjit Mazumder
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  2. Shyamali Mukherjee
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  3. Parimal C. Sen
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Mazumder, B., Mukherjee, S. & Sen, P.C. The chlorpromazine inhibition of transport ATPase and acetylcholinesterase activities in the microsomal membranes of rat in vitro and in vivo . Mol Cell Biochem 95, 13–20 (1990). https://doi.org/10.1007/BF00219525

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  • DOI: https://doi.org/10.1007/BF00219525

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