Abstract
Sixty-two patients of two institutions for mentally retarded patients were immunized intradermally with 4 ug doses of plasma-derived hepatitis B vaccine made in Japan, initially at month 0,1, and 6. The three vaccinations induced antibodies in 93.5% (90.9% in those with Down's syndrome (DS), 94.1% in other forms of mental retardation (OMR)) of the vaccinees within 9 months after the first injection, and the percentage of geometric mean titers of antibody above 10 mIU/ml was 89.3% (81.8% DS, 84.3% OMR) within 9 months. Within 2 years, the seroconversion rate showed a significantly higher decrease in subjects with DS (54.5%) than in OMR (86.3%), and the percentage of vaccinees with above 10 mIU/ml also showed a significantly higher decrease in subjects with DS (36.4%) than in those with OMR (74.5%) (p < 0.05). In the OMR patients, the antibody response persisted for 2 years, decreased remarkedly in the DS patients.
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References
ChaudharyR.K., PenyE. and ClearyT.E. (1977): Prevalence of hepatitis B infection among residents of an institution for mentally retarded - Am. J. Epidemiol. 105: 123–126.
DudleyF.J., FoxR.A. and SherlockS. (1972): Cellular immunity and hepatitis-associated Australia antigen liver disease - Lancet i: 723–726.
FaddaG., MaidaA., MasiaC., ObinoG., RomanoG. and SpanoE. (1987): Efficacy of hepatitis B immunization with reduced intradermal doses - Eur. J. Epidemiol. 3: 176–180.
HayashiJ., KashiwagiS., NoguchiA., NakashimaK., IkematsuH., KajiyamaW. and NomuraH. (1989): Hepatitis B virus infection among mentally retarded patients in institutions, Okinawa, Japan - Fukuoka Acta Med. 80: 436–440.
HayashiJ., KashiwagiS., NoguchiA., NakashimaK., IkematsuH. and KajiyamaW. (1989): Intradermal hepatitis B vaccination for mentally retarded patients- J. Infect. 19: 119–125.
HayashiJ., KashiwagiS., NomuraH., KajiyamaW. and IkematsuH. (1987): The control of hepatitis B virus infection with vaccine in Japanese nursery schools - Am. J. Epidemiol. 126: 474–479.
HayashiJ., KashiwagiS., IkematsuH., NoguchiA. and IkedaK. (1988): Long term observation for immunogenicity of hepatitis B vaccine in hospital personnel (In Japanese) - J. Jpn. Assoc. Infect. Dis. 62: 805–810.
HeijtinkR.A., BreukersA.A.E.M., HartighG.D., SchepmanR.W.M., SchmitzR.I.M., SchalmS.W. and MasurelN. (1988): Low dose intradermal vaccination against hepatitis B in mentally retarded patients -Vaccine 6: 59–61.
HeijtinkR.A., JongR.D., SchalmS.W. and MasurelN. (1984): Hepatitis B vaccination in Down's syndrome and other mentally retarded patients - Hepatology 4: 611–614.
HollingerF.B. (1981): Response to hepatitis B vaccine in a young adult population. In: Szmuness W., Alter H.J., Maynard J.E. - Eds. Viral hepatitis - Philadelphia, Franklin Institute Press 451–456.
JilgW., SchmidtM., DeinhardtR. and ZachovalR. (1984): Hepatitis B vaccination: How long does proportion last? - Lancet i: 458.
KashiwagiS., NagafuchiS., InoueT., HayashiS., TakeshitaS. and ImayamaS. (1984): Development of DTH skin reaction to HBsAg in individuals immunized with HB vaccine - Microbiol. Immunol. 28: 1335–1338.
MillerK.D., GibbsR.D., MulliganM.M., NutmanT. and FrancisD.P. (1983): Intradermal hepatitis B virus vaccine. Immunogenicity and side-effects in aldults -Lancet ii: 1454–1456.
NagafuchiS. and KashiwagiS. (1987): Revasal by intradermal hepatitis B vaccination of unresponsiveness to HBsAg - Lancet ii: 1522–1523.
RedfieldR.R., InnisB.L., ScottR.M., CannonH.G. and BancroftW.H. (1985): Clinical evaluation of low-dose intradermally administrated hepatitis B virus vaccine. A cost reduction strategy - JAMA 254: 3203–3206.
RigasD.A., ElsasserP. and HechtF. (1970): Impaired in vitro response of circulating lymphocytes to phytohemagglutinin in Down's syndrome. Dose- and time-response curves and relation to cellular immunity - Intern. Arch. Allergy 39: 587–608.
SzmunessW. and PrinceA.M. (1971): The epidemiology of serum hepatitis (SH) infection. A controlled study in two closed institutions - Am. J. Epidemiol. 94: 585–595.
TroisiC.L., HeibergD.A. and HollingerF.B. (1985): Normal immune response to hepatitis B vaccine in patients with Down's syndrome. A basis for immunization guidelines - JAMA 254: 3196–3199.
VanDitzhuijsenTh.J.M., deWitte-van der ScootE.vanLoonA.M., RijntjesP.J.M. and YapS.H. (1988): Hepatitis B virus infection in an institution for the mentally retarded - Am. J. Epidemiol. 128: 629–638.
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Hayashi, J., Noguchi, A., Nakashima, K. et al. Long term observation of the effect of intradermal hepatitis B vaccination on mentally retarded patients. Eur J Epidemiol 7, 649–653 (1991). https://doi.org/10.1007/BF00218676
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DOI: https://doi.org/10.1007/BF00218676