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Circadian rhythms of indoleamines and serotonin N-acetyltransferase activity in the pineal gland

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Conclusion

The circadian rhythm of melatonin synthesis in the pineal glands of various species has been summarized. The night-time elevation of melatonin content is in most if not all cases regulated by the change of N-acetyltransferase activity. In mammals, the N-acetyltransferase rhythm is controlled by the central nervous system, presumably by suprachiasmatic nuclei in hypothalamus through the superior cervical ganglion. In birds, the circadian oscillator that regulates the N-acetyltransferase rhythm is located in the pineal glands. The avian pineal gland may play a biological clock function to control the circadian rhythms in physiological, endocrinological and biochemical processes via pineal hormone melatonin.

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  1. Department of Medical Chemistry, Tokyo Metropolitan Institute for Neurosciences, 2-6, Musashidai, 183, Fuchu-city, Tokyo, Japan

    Takeo Deguchi

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Deguchi, T. Circadian rhythms of indoleamines and serotonin N-acetyltransferase activity in the pineal gland. Mol Cell Biochem 27, 57–66 (1979). https://doi.org/10.1007/BF00217793

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