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Reconstruction of rat skeletal muscle glycerophosphate shuttle

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Summary

The activity of α-glycerophosphate shuttle in homogenate and in a reconstructed system (isolated mitochondria and cytoplasm) from rat skeletal muscle is presented. The influence of some inhibitors of mitochondria) α-glycerosphate dehydrogenase on the activity α-glycerophosphate shuttle is demonstrated. The possible operativity of α-glycerophosphate shuttle in skeletal muscle in vivo is discussed.

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Abbreviations

CCCP:

carbonyl cyanide mchlorophenyl hydrazone

DHAP:

dihydroxyacetone phosphate

F-1,6 P2 :

fructose 1,6 diphosphate

α-GP:

α-glycerophosphate

GAP:

glyceraldehyde 3-phosphate

PEP:

phosphoenolpyruvate

3-PG:

3-phosphoglycerate

PYR:

pyruvate

PAL-CoA:

palmitoyl CoA

MIT:

mitochondria

CYT:

cytoplasm

PAL-CARN:

palmitoyl carnitine

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Authors and Affiliations

  1. Department of Biochemistry, IBM, Medical School, ul. Dębinki 80-211, Gdánsk, Poland

    P. W. D. Ścisłowski, J. Świerczyński, Z. Aleksandrowicz & M. Żydowo

Authors
  1. P. W. D. Ścisłowski
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  2. J. Świerczyński
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  3. Z. Aleksandrowicz
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  4. M. Żydowo
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Ścisłowski, P.W.D., Świerczyński, J., Aleksandrowicz, Z. et al. Reconstruction of rat skeletal muscle glycerophosphate shuttle. Mol Cell Biochem 27, 3–6 (1979). https://doi.org/10.1007/BF00217788

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  • DOI: https://doi.org/10.1007/BF00217788

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