Summary
By use of immunocytochemistry, a gastrin/CCK-like material has been demonstrated in the corpus cardiacum-corpus allatum complex of the cockroach Leucophaea maderae. Reactivity toward gastrin and CCK with region-specific antisera suggests that the gastrin/CCK-like peptide of this insect contains the COOH-terminal tetrapeptide sequence which is common to gastrin and CCK, and that the material is more gastrin-like than CCK-like. The results indicate that, like other neuropeptides, the gastrin/CCK peptide family appeared early in evolution within neuronal elements, and that the COOH-terminal region of gastrin has been conserved during phylogeny.
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Supported in part by SNF grant 11-5082 (G.N.H.) and NIH Grant NS22344-02 (B.S.). We thank Drs. Lars-Inge Larsson and Jens F. Rehfeld for the generous gifts of antisera 2717, 4713, and 4698
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Hansen, G.N., Hansen, B.L. & Scharrer, B. Gastrin/CCK-like immunoreactivity in the corpus cardiacum-corpus allatum complex of the cockroach Leucophaea maderae . Cell Tissue Res. 248, 595–598 (1987). https://doi.org/10.1007/BF00216488
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DOI: https://doi.org/10.1007/BF00216488