Summary
In a study of the effect of pinealectomy on thyroid C-cell number, 8 animals out of 66 were found to have thymic tissue in close association with the thyroid. Cells containing immunoreactive calcitonin were found in all of the thyroids but in only one of the 8 pieces of thymus. These cells found in a piece of thymic tissue associated with the right thyroid lobe were located immediately under the capsule and did not form or associate with follicles. Unlike the other animals the rat with thymic calcitonin cells had an unequal distribution of C-cells between the left and right thyroid lobes, but the total number of thyroidal C-cells was the same as that of the other rats. Since the thymus proper was not examined in these 66 animals, ten additional rats were taken for such a study. Thyroid-associated thymic tissue was found in three of these, but none of these thymi showed any immunoreactive cells.
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Bugnon C, Fellman D, Blähser S, Maurat JP, Bloch B (1978) Etude cyto-immunologique des cellules C avec des immunsérums anticalcitonine ou anti-somatostatine chez des rats traités par la vitamine D, la thyroxine ou le benzyl-thiouracile. CR Soc Biol (Paris) 172:691–696
Engen PC, Wheeler R (1978) N-butyl methacrylate and paraffin as an embedding medium for light microscopy. Stain Technol 53:17–22
Fontaine J (1979) Multistep migration of calcitonin cell precursors during ontogeny of the mouse pharynx. Gen Comp Endocrinol 37:81–92
Galante L, Gudmundsson TV, Mathews EW, Tse A, Williams ED, Woodhouse NJY, MacIntyre I (1968) Thymic and parathyroid origin of calcitonin in man. Lancet 2:537–538
Godwin MC (1937) Complex IV in the dog with special emphasis on the relation of the ultimobranchial body to the interfollicular cells in the postnatal thyroid gland. Am J Anat 60:299–339
Hoyt Jr RF, Hamilton DW, Tashjian Jr AH (1973) Distribution of thyroid, parathyroid and ultimobranchial hypocalcemic factors in birds. II. Morphology, histochemistry and hypocalcemie activity of pigeon thyroid glands. Anat Rec 176:1–34
McMillan PJ, Hooker WM, Deftos LJ (1974) Distribution of calcitonin-containing cells in the human thyroid. Am J Anat 140:73–79
McMillan PJ, Hooker WM, Roos RA, Deftos LJ (1976) Ultimobranchial gland of the trout (Salmo gairdneri). I. Immunohistology and radioimmunoassay of calcitonin. Gen Comp Endocrinol 28:313–319
Pearse AGE, Carvalheira AF (1967) Cytochemical evidence for an ultimobranchial origin of rodent thyroid C cells. Nature 214:929–930
Pearse AGE, Polak JM (1971) Cytochemical evidence for the neural crest origin of mammalian ultimobranchial C cells. Histochemie 27:96–102
Sehe CT (1965) Comparative studies on the ultimobranchial body in reptiles and birds. Gen Comp Endocrinol 5:49–59
Swarup K, Das VK (1978) Calcitonin cells and unusual follicle in four month old Wistar rats. Z Mikrosk Anat Forsch 92:212–221
Swarup K, Srivastav AK, Tewari NP (1978) Occurrence of calcitonin cells and cysts in the parathyroid of the house shrew, Suncus murinus. Acta Anat (Basel) 101:340–345
Treilhou-Lahille F, Cressent M, Taboulet J, Moukhtar MS (1979) Immunohistochemical staining of mouse C cells during postnatal histogenesis of the thyroid. Histochemistry 63:69–80
Wechbanjong N, McMillan PJ, Dalgleish AE (1979a) Influence of development on the number of calcitonin-containing cells in the mouse thyroid. Am J Anat 154:477–488
Wechbanjong N, McMillan PJ, Dalgleish AE (1979b) Mouse ultimobranchial body not mixed with the thyroid: Four cases. Anat Histol Embryol 8:160–163
Wolfe HJ, Voelkel EF, Tashjian Jr AH (1974) Distribution of calcitonin-containing cells in the normal adult human thyroid gland: A correlation of morphology with peptide content. J Clin Endocrinol Metab 38:688–694
Wollman SH, Nève P (1971) Postnatal development and properties of ultimobranchial follicles in the rat thyroid. Anat Rec 171:247–258
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Financial support by the Deutsche Forschungsgemeinschaft (grant Vol 35/7) is gratefully acknowledged
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McMillan, P.J., Heidbüchel, U. & Vollrath, L. Anomalous occurrence of immunoreactive calcitonin cells in the thymus of the rat. Cell Tissue Res. 222, 629–634 (1982). https://doi.org/10.1007/BF00213860
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DOI: https://doi.org/10.1007/BF00213860