Summary
The ultrastructure of Pacinian corpuscles located on the crural interosseous membrane was studied in adult rats 6 h to 10 months after transection of the right sciatic nerve. Axon terminals degenerated one day after transection and were engulfed and resorbed by cells of the inner core within one week. The axial space left after removal of the axonal debris was closed by the lamellae of the inner core. The main structural features of the inner core and capsule remained preserved after denervation throughout the period of study. The denervated inner cores, however, became atrophic 10 months after neurotomy, their mean diameter being reduced by 17.5% compared with that of contralateral control corpuscles. The number of capsular lamellae was unaltered, and perineurial pathways of the peripheral nerve stump remained preserved. Schwann cells proliferated and formed Büngner bands during the first month after denervation, but retracted their processes and became atrophic at later stages after neurotomy.
Survival of Pacinian corpuscles after long-term denervation in adult rats is in contrast to their rapid degeneration within several days after nerve section in neonates.
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References
Bannister LH (1976) Sensory terminals of peripheral nerves. In: Landon DN (ed) The peripheral nerve. Chapman and Hall, London, pp 396–463
Burgness PR, English KB, Horch KW, Stensaas LJ (1974) Patterning in the regeneration of type I cutaneous receptors. J Physiol 236:57–82
Chouchkov Ch (1971) Ultrastructure of Pacinian corpuscles after the section of nerve fibres. Z Mikrosk Anat Forsch 83:33–46
Chouchkov Ch (1979) Degeneration and regeneration of some mechanoreceptors. An ultrastructural study. I. Ultrastructure of denervated Herbst corpuscles. Z Mikrosk Anat Forsch 93:353–364
Hunt CC (1974) The Pacinian corpuscle. In: Hubbard JI (ed) The peripheral nervous system. Plenum Press, London, pp 374–404
Korthals JK, Wisniewski HM, Ghetti B, Cook RD (1974) The fate of the axon and its terminal in the Pacinian corpuscle following sciatic nerve section. J Neurocytol 3:385–403
Krishnamurti A, Kanagasuntheram R, Vij S (1973) Failure of reinnervation of Pacinian corpuscle after nerve crush. Acta Neuropathol 23:338–341
Munger BL (1971) Patterns of organization of peripheral sensory receptors. In: Loewenstein WR (ed) Principles of receptor physiology. Handbook of sensory physiology Vol 1. Springer, Berlin, pp 523–556
Nishi K, Oura C, Pallie W (1969) Fine structure of Pacinian corpuscles in the mesentery of the cat. J Cell Biol 43:539–552
Otelin AA, Mashansky VF, Mirkin AS (1976) Teltse Vater-Pacini. Nauka, Leningrad
Pease DC, Quilliam TA (1957) Electron microscopy of the Pacinian corpuscle. J Cell Biol 3:331–342
Polàček M, Mazanec K (1966) Ultrastructure of mature Pacinian corpuscles from mesentery of adult cat. Z Mikrosk Anat Forsch 75:343–354
Saxod R (1978) Development of cutaneous sensory receptors in birds. In: Jacobson M (ed) Development of sensory systems. Handbook of sensory physiology, Vol IX. Springer, Berlin Heidelberg New York, pp 337–417
Spencer PS, Schaumburg HH (1973) An ultrastructural study of the inner core of Pacinian corpuscle. J Neurocytol 2:217–235
Weinberg HJ, Spencer PS (1978) The fate of Schwann cells isolated from axonal contact. J Neurocytol 7:555–569
Zalewski AA (1974) Neuronal and tissue specifications involved in taste bud formation. Ann NY Acad Sci 228:344–349
Zelená J (1964) Development, degeneration and regeneration of receptor organs. Prog Brain Res 13:175–211
Zelená J (1976) The role of sensory innervation in the development of mechanoreceptors. Prog Brain Res 43:59–64
Zelená J (1980) Rapid degeneration of developing Pacinian corpuscles after denervation. Brain Res 187:97–111
Zelená J, Hník P (1963) Effect of innervation on the development of muscle receptors. In: Gutmann E, Hník P (eds) The effect of use and disuse on neuromuscular functions. Academia, Prague, pp 95–105
Zelená J, Sobotková M, Zelená H (1978) Age-modulated dependence of Pacinian corpuscles upon their sensory innervation. Physiol Bohemoslov 27:437–443
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Zelená, J. Survival of Pacinian corpuscles after denervation in adult rats. Cell Tissue Res. 224, 673–683 (1982). https://doi.org/10.1007/BF00213762
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DOI: https://doi.org/10.1007/BF00213762