Skip to main content
SpringerLink
Log in

Poliomyelitis immunity status at different intervals from vaccination

  • Published:
European Journal of Epidemiology Aims and scope Submit manuscript

Abstract

Research on neutralizing antibodies against the 3 serotypes of poliovirus was carried out on 441 blood specimens drawn from children and young people living in Parma, a town of about 200.000 inhabitants, where the vaccination services were well organized. From June 1983 to June 1984 blood samples were taken from different groups of subjects at different stages of vaccination (before vaccination, and after 1, 2, 3, and 4 doses of trivalent balanced OPV).

In addition, groups of children and young people vaccinated from 2 to more than 14 years earlier were bled. Ten per cent of unvaccinated babies (aged 1–3 months) were lacking in neutralizing antibodies for types 1 and 3 and five per cent for type 2; among children aged 4–5 months vaccinated by one dose of OPV a residual 5% of subjects without antibodies for type 1 was also found.

All subjects who received two, three, or four doses, had antibodies against all serotypes of poliovirus.

As for the number of administered doses, significant differences among GMTs of antibodies were recorded only for type 1, when the group given 3 doses, was compared with the group which received two and one dose, respectively.

At different intervals from completion of vaccination (2–14 years), all groups we examined still had antibodies against all three serotypes.

For poliovirus type 1 antibody, GMTs were not significantly different in the examined groups. For types 2 and 3 significant decreases were observed in the groups vaccinated from 2 to 5 years.

The high levels of immunity observed earlier in Parma were not found throughout the entire territory. Of 69 subjects living in a remote mountain village (65 km from Parma) the prevalence of seronegatives was about 6% for types 1 and 3, 6–9 years after vaccination and about 8% for type 1, 10–13 years after.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Belian W. (1967): Poliomyelitis antibody statistical survey in the G.D.R. after 6 years of systematical oral inoculation with attenuated virus using poliomyelitis live vaccine type Sabin - Tschumakow. XI Symposium Ass. Europ. Poliomyèlite et Maladies Assoeiées. Rome 9–12 Oct. 1966. Ed. Masson, Paris.

    Google Scholar 

  2. Bey E. and Golombick T. (1984): A comparison of three methods for titration of poliovirus vaccines.- J. Virol. Meth., 9: 123–130.

    Google Scholar 

  3. Biffi M.R., Tagger A., Bruscolini F., Salvaggio L. and Albano A. (1982): Escrezione fecale di poliovirus in soggetti sottoposti a vaccinazione antipoliomielitica.- N. Ann. d'Ig. e Microb., 33: 285–294.

    Google Scholar 

  4. Burke D.S., Gaydos J.C., Hodder A.R. and BancroftH.W. (1979): Seroimmunity to polioviruses in U.S. Army recruits. - J. Inf. Dis., 139: 225–227.

    Google Scholar 

  5. Cellesi C. and Rossolini A. (1984): La vaccinazione antipoliomielitica. - Fed. Med. Chir., 6: 13–16.

    Google Scholar 

  6. Cesario T.C., Jones V., Poland P.D. and Chin T.D.Y. (1969): Persistence of poliovirus neutralizing antibodies four years after immunization with live attenuated vaccine. - Am. J. Epidemiol., 90: 157–161.

    Google Scholar 

  7. Collingham K.E. and Pollock M.T. (1978): Paralytic poliomyelitis in England and Wales 1976–7. - The Lancet, 7: 976–977.

    Google Scholar 

  8. Cood A.A. and White E. (1977): Protection against poliomyelitis. - The Lancet, 11: 1078.

    Google Scholar 

  9. Editorial (1981) : Monitoring of circulation of poliovirus in waste water. - Wkly Epidem. Rec., 56: 105.

  10. Editorial (1981) : Poliomyelitis 1980. Part I. - Wkly Epidem. Rec., 56: 329–333.

  11. Editorial (1983): Poliomyelitis surveillance. - Wkly Epidem. Rec., 58: 271.

  12. Editorial (1983): Poliomyelitis surveillance. - Wkly Epidem. Rec., 58: 292–293.

  13. Editorial (1983): Poliomyelitis in 1982. - Wkly Epidem. Rec., 58: 385–390.

  14. Editorial (1984): Poliomyelitis surveillance. - Wkly Epidem. Rec., 59: 82.

  15. Ferrante P., Barbi M. e Fasan M. (1980): Stato attuale della immunità verso la poliomielite della popolazione di Milano. Risultati preliminari. - Ig. Moderna, 74: 917–925.

    Google Scholar 

  16. Freestone D.S., Kelly A., Ferris R., Simmons R.L.L., Bowker C., Letley E. and Bye C. (1980): Comparison of antibody responses and virus shedding following administration of trivalent oral poliomyelitis vaccines prepared either in monkey kidney or human diploid cell substrates. - J. Hvg. Comb., 84: 17–28.

    Google Scholar 

  17. Furesz J., Armstrong R.E. and Contrera G. (1978): Viral and epidemiological links between poliomyelitis outbreaks in unprotected communities in Canada and the Netherlands. - The Lancet, 11: 1248.

    Google Scholar 

  18. Giuliani G., Frezet D., Paggi G.C. and Varetti G. (1982): Indagini sullo stato immunitario umorale antipoliomielitico della popolazione piemontese a 15 anni dall'introduzione della vaccinazione con vaccino orate di Sabin. - Ann. Sclavo, 24: 5–15.

    Google Scholar 

  19. Grinstein S., Melnick J.L. and Wallis C. (1970): Isolation from sewage and from a stream receiving affluents of sewage treatment plants. - Bull. WHO, 42: 291.

    Google Scholar 

  20. Hinman A.R. (1984): Mass vaccination against polio. - JAMA, 251: 2994–2996.

    Google Scholar 

  21. Horstmann D.M. (1982): Control of poliomyelitis: a continuing paradox, - J. Inf. Dis., 146: 540–551.

    Google Scholar 

  22. Just M. and Ritzel G. (1966): The immune-status of schoolchildren against poliomyelitis six and four years after vaccination with live poliovirus vaccine. XI Simposium Assoc. Europ. Poliomyèlite et Maladies Associées. Rome, 9–12 Oct., 1966. Ed. Masson, Paris.

    Google Scholar 

  23. Kašovà V., Koza J. and Matyšova I. (1981): High and prolonged incidence of poliovirus strains during 1979 in north Bohemia. Isolations from unusual materials. - Zbl. Bakt. Hyg. 1. Abt. Orig. A, 251: 1–14.

    Google Scholar 

  24. Lamb G.A., Plexico K., Glezen W.P. and Chin T.D.Y. (1965): Use of microtechnique for serum neutralization and virus identification. - Publ. Health Rep., 80: 463–466.

    Google Scholar 

  25. Lamy M.E. (1980): Results of poliomyelitis vaccination in Belgium. Excerpta Med., Sect. 17, 34: 576.

    Google Scholar 

  26. Mayer R.T. and Balfour H.H. (1981): Prevalence of poliovirus neutralizing antibodies in young adult women. - JAMA, 246: 1207–1209.

    Google Scholar 

  27. Metselaar D., McDonald K., Gemert W., VanRensM.M. and Muller A. (1977): Poliomyelitis: epidemiology and prophylaxis. 5. Results of a two —and three — dose vaccination experiment. - Bull. WHO, 55: 755–759.

    Google Scholar 

  28. Monaci V., Vitali M.A., Trombetta N., Bellelli E. and Nardi G. (1966): Stato immunitario dopo 1 anno dalla rivaccinazione antipoliomielitica orale con vaccino trivalente attenuato Sabin. - Ann. Sclavo, 8: 244–254.

    Google Scholar 

  29. Monaci V., Yitali M.A., Trombetta N., Bellelli E. and Nardi G. (1967): Status of immunity -one year after antipolio revaccination by trivalent attenuated vaccine (Sabin) in some zones of Northern Italy. XI Symposium Ass. Europ. poliomyèlite et maladies associeés, Rome, 9–12 Oct. 1966. Ed. Masson, Paris.

    Google Scholar 

  30. Monaci V., Nardi G. and Bellelli E. (1971): Stato immunitario della popolazione verso la poliomielite (Nota I). - Ann. Sclavo, 13: 305–32.

    Google Scholar 

  31. Moore M., Katona P.; Kaplan E.J., SchonbergerL.B. and Hatch M.H. (1982): Poliomyelitis in the United States 1969–1981. - J. Inf. Dis., 146: 558–563.

    Google Scholar 

  32. Mortimer P.P. and Cunningham P. (1975): Seroimmunity to poliovirus in children and young women: England 1972–4. - J. Hyg. Camb., 74: 283–287.

    Google Scholar 

  33. Nardi G., Bellelli E., Tanzi M.L., Bracchi U., MonaciV. and Corsello A. (1971): Stato immunitario verso la poliomielite in vari gruppi di popolazione. Nota II. - Ann. Sclavo, 13: 553–566.

    Google Scholar 

  34. Oberhofer T.R., Brown C.G. and Monto S.A. (1975): Seroimmunity to poliomyelitis in an american community. - Am. J. Epidemiol., 101: 333–339.

    Google Scholar 

  35. Rangelova S.M. (1982): Control of poliomyelitis in Bulgaria: experience of two decades. - Progres Med. Virol., 31: 183–211.

    Google Scholar 

  36. Roebuck M. and Chamberlain R. (1982): Prevalence of antibodies to poliovirus in 1978 among subjects aged 0–88 years. - B.M.J., 284: 697–700.

    Google Scholar 

  37. Sabin A.B. (1980): Vaccination against poliomyelitis in economically underveloped countries. - Bull. WHO, 58: 141–157.

    Google Scholar 

  38. Sabin A.B. and Silva E. (1983): Residual paralytic poliomyelitis in a tropical region of Brazil, 1969–1977: prevalence surveys in different age groups as indicators of changing incidence. - Am. J. Epidemiol., 117: 193–200.

    Google Scholar 

  39. Santoro R., Lombardi F., Novello F., Amato C., Ruggeri M.F., Grandolfo H.E., Annesi I., CoriellessaC.M., Timperi F. and Inglese R. (1984): Serum antibodies to poliomyelitis in Italy. - Bull. WHO, 62: 591–595.

    Google Scholar 

  40. Stagni G., Merletti L. and DeRosa F. (1979): Livelli di anticorpi specifici per i virus poliomielitici e grado di protezione immunitaria nella popolazione umbra. - Boll. Ist. Sieroter. Mil., 58: 210–215.

    Google Scholar 

  41. SulliMn E.J. and Rosembaum M.S. (1967): Methods for preparing tissue colture in disposable microplates and their use in virology. - Am. J. Epidemiol., 85: 424–437.

    Google Scholar 

  42. Tanzi M., Bracchi U. and Bellelli E. (1984): Anticorpi neutralizzanti i tre virus poliomielitici in sieri materni e neonatali. - Ig. Moderna, 82: 330–346.

    Google Scholar 

  43. Trivello R., Romano M., Moschen M.E. and Rausa G. (1979): Immunità umorale antipoliomielitica in bambini delle scuole materne a varia distanza di tempo dalla somministrazione del vaccino Sabin.- Ig. Moderna, 72: 536–547.

    Google Scholar 

  44. Trombetta N., Bellelli E., Nardi G., Vitali M.A. Monaci V. (1967): Stato immunitario dopo 2 anni dalla rivaccinazione antipoliomielitica orale con vaccino trivalente Sabin. - Ann. Sclavo, 9: 414–422.

    Google Scholar 

  45. Volpi A., Ragona G., Biondi W., Rocchi G. and Archetti T. (1976): Seroimmunity to polioviruses in an urban population of Italy. - Bull. WHO, 54: 275–278.

    Google Scholar 

  46. Weise H.J. (1980): Poliomyelitis in the GFR (including West Berlin) in 1968–1977. - Excerpta Med., Sect. 17, 34: 162.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto di Igiene, Centro di Virologia dell'Università di Parma, Via Gramsci, 14, 43100, Parma, Italy

    E. Bellelli, U. Bracchi & M. L. Tanzi

  2. Divisione Pediatrica degli Ospedali Riuniti di Parma, Italy

    G. Benaglia & G. Montanarini

Authors
  1. E. Bellelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. U. Bracchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. L. Tanzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G. Benaglia
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Montanarini
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Corresponding author

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bellelli, E., Bracchi, U., Tanzi, M.L. et al. Poliomyelitis immunity status at different intervals from vaccination. Eur J Epidemiol 2, 197–204 (1986). https://doi.org/10.1007/BF00211532

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00211532

Key words

Search

Navigation