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Influence of natural and synthetic inhibitors on the crystallization of calcium oxalate hydrates

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Summary

The kinetics of crystallization of calcium oxalate monohydrate was studied in the presence of polyacrylate, and the growth of both this salt and the trihydrate was investigated in the presence of polyasparatic acid, polyglutamic acid, and heparin. We monitored the crystallization reactions either by following the change in lattice-ion concentrations as a function of time or by maintaining constant supersaturation via the replacement of lattice ions during the experiments. In addition, the crystallization reactions of calcium oxalate monohydrate, dihydrate, and trihydrate were studied in the presence of urine fractions (5%, v/v) separated by molecular weight in the range of 1 000–50 000 Da from whole urine.

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Authors and Affiliations

  1. American Dental Association Health Foundation, Paffenbarger Research Center, Polymer Division, National Institute of Standards and Technology, 20899, Gaithersburg, MD

    B. B. Tomazic

  2. Chemistry Department, State University of New York at Buffalo, 114214, Buffalo, NY, USA

    M. E. Sheehan & G. H. Nancollas

Authors
  1. B. B. Tomazic
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  2. M. E. Sheehan
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  3. G. H. Nancollas
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Additional information

This study was supported in part by grant Ro1-AM 19048 from the National Institutes of Arthritis, Diabetes and Kidney Diseases, National Institutes of Health. All experimental work was performed at the Department of Chemistry, State University of New York at Buffalo. Certain commercial materials and equipment are identified in this paper to specify the experimental procedure. In no instance does such identification imply recommendation or endorsement by the National Institute of Standards and Technology or the ADA Health Foundation or that the materials or equipment identified are necessarily the best available for the purpose

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Tomazic, B.B., Sheehan, M.E. & Nancollas, G.H. Influence of natural and synthetic inhibitors on the crystallization of calcium oxalate hydrates. World J Urol 10, 216–225 (1992). https://doi.org/10.1007/BF00208913

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