Summary
Cells derived from HSV-induced tumour lines were attenuated by X-irradiation (15,000 rads) and used to immunize groups of hamsters prior to challenge with homologous tumour cells. The results indicate that the three HSV tumours studied possess a weak transplantation antigen(s). Some cross-immunity between these tumours was observed, although the rejection antigen(s) were distinct from those of a SV40-induced hamster tumour line.
Bacillus Calmétte-Guérin (BCG) inoculated in admixture with X-irradiated tumour cells or given 7 days prior to immunization with X-irradiated tumour cells increased host immunocompetence to subsequent tumour cell challenge. Thus, immunization with BCG was shown to induce a higher level of immunity than immunization with attenuated tumour cells alone, as demonstrated on re-challenge of hamsters with homologous tumour cells.
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Mousawy, K.M., Rees, R.C. & Potter, C.W. Immunogenic properties of hamster tumours of herpesvirus hominis aetiology. Cancer Immunol Immunother 8, 119–126 (1980). https://doi.org/10.1007/BF00205661
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DOI: https://doi.org/10.1007/BF00205661