Abstract
A small, nonmagnetic coil was fluoroscopically guided into the left circumflex coronary artery (LCXA) at the midventricular level via the left femoral artery in seven rabbits. Coronary artery occlusion was confirmed by intracoronary contrast injection, electrocardiographic changes, akinesis of the posterolateral wall distal to the occluded area, and histopathological staining of the myocardium. This new model of a closed-chest coronary artery occlusion in the rabbit may be suitable for acute ischemic myocardium studies that do not require reperfusion.
Similar content being viewed by others
References
Tscholakoff D, Higgins CB, Sechtem U, Caputo G, Derugin N (1986) Magnetic resonance imaging of reperfused myocardial infarcts in dogs. AJR 146:925–930
Tscholakoff D, Higgins CB, McNamera M, Derugin N (1986) Early phase myocardial infarction: Evaluation by MR imaging. Radiology 159:667–672
Saeed M, Wendland M, Masui T, Connolly A, Derugin N, Brasch R, Higgins CB (1991) Myocardial infarction: Assessment with an intravascular MR contrast medium. Radiology 180(1):153–160
Wendland M, Saeed M, Masui T, Derugin N, Moseley M, Higgins CB (1993) Echo-planar imaging of normal and ischemic myocardium with gadodiamide injection. Radiology 186:535–542
Maxwell MP, Hearse DJ, Yellon DM (1987) Species variation in the coronary collateral circulation during regional myocardial ischemia: A critical determinant of the rate of evolution and extent of myocardial infarction. Cardiovasc Res 21:737–746
Coker S (1989) Anesthetized rabbit as a model of ischemia- and reperfusion-induced arrythmias: Effect of quinidine and bretylium. J Pharmocol Mem 21:263–279
Miura T, Downey J, Ooiwa H, Ogawa S, Adachi T, Noto T, Shizukuda Y, Iimura O (1989) Progression of myocardial infarction in a collateral flow-difficient species. Jap Heart J 30:(5);695–708
Harken AH, Simson MB, Haselgrove J, Wetstein L (1981) Early ischemia after complete coronary ligation in the rabbit, dog, pig and monkey. Am J Physiol 241:H202-H210
Chagrasulis RW, Downey JM (1977) Selective coronary embolization in closed chest dogs. Am J Physiol 232:H335-H337
Naslund U, Haggmark S, Johansson G, Marklund SL, Reiz S (1990) Limitations of myocardial infarct size by superoxide dismutase as an adjunct to reperfusion after different durations of coronary occlusion in the pig. Circ Res 66:(5);1294–1301
Cohen MV, Elah P (1973) Experimental myocardial infarction in the closed-chest dog: Controlled production of large or small areas of necrosis. Am Heart J 86:798–804
Wolfe CL, Moseley ME, Wikstrom MG, Sievers RE, Wendland MF, Dupon JW, Finkbeiner WE, Lipton MJ, Parmley WW, Brasch RC (1989) Assessment of myocardial salvage after ischemia and reperfusion using magnetic resonance imaging and spectroscopy. Circulation 80:969–982
Fishbein MC, Meerbaum S, Rit J, Lando U, Kanmatsuse K, Mercier JC, Corday E, Ganz P (1981) Early phase acute myocardial infarct size quantification: Validation of the triphenoltetrazolium chloride tissue enzyme staining technique. Am Heart J 101:593–600
Klein HH, Puschmann S, Schaper J, Schaper W (1981) The mechanism of tetrazolium reaction in identifying experimental myocardial infarction. Virchows Arch [A] 393:287–297
Schaper W, Frenzel H, Hart W (1979) Experimental coronary artery occlusion: 1. Measurement of infarct size. Basic Res Cardiol 74:46–53
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Derugin, N., Masui, T. & Konishi, Y. A new model for occluding the left coronary artery in the rabbit without thoracotomy. Cardiovasc Intervent Radiol 18, 340–342 (1995). https://doi.org/10.1007/BF00203690
Issue Date:
DOI: https://doi.org/10.1007/BF00203690