Abstract
By using the non-isotopic single-strand conformation polymorphism (SSCP) technique to analyse products of the polymerase chain reaction (PCR), we detected a 561-adenine to cytosine substitution resulting in an amino acid exchange from serine to arginine at position 128 of the E-selectin gene. If this amino acid substitution has an effect on the adhesion of blood cells to the endothelium, the polymorphism could be of interest with respect to association studies in a number of pathological conditions, such as cardiovascular diseases.
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References
Bevilacqua MP, Stengelin S, Gimbrone MA, Seed B (1989) Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 243:1160–1165
Collins T, Williams A, Johnston GI, Kim J, Eddy R, Shows T, Gimbrone MA, Bevilacqua MP (1991) Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1*. J Biol Chem 266:2466–2473
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Wenzel, K., Hanke, R. & Speer, A. Polymorphism in the human E-selectin gene detected by PCR-SSCP. Hum Genet 94, 452–453 (1994). https://doi.org/10.1007/BF00201614
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DOI: https://doi.org/10.1007/BF00201614