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Immunhistochemischer Arzneimittelnachweis in Autopsiematerial

Immunohistochemical identification of drugs in autopsy material

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Summary

Drugs (barbiturates) could be qualitatively identified in formalinfixed and in paraffin-embedded autopsy material, as well as in fresh-frozen unfixed tissue by using the PAP method. Sensitivity could be considerably increased by application of an additional antibody. The practical use of this kind of determination is the possibility of retrospective examination if more suitable material is not available.

Zusammenfassung

An formalinfixiertem und in Paraffin eingebettetem Autopsiematerial und an Kryostatschnitten wurden mittels PAP-Methode Arzneimittel (Barbiturate) qualitativ nachgewiesen. Die Sensitivität konnte durch einen zwischengeschalteten Antikörper erheblich verstärkt werden. Die praktische Bedeutung dieses Nachweises liegt in der Möglichkeit nachträglicher Untersuchungen, wenn geeigneteres Material nicht zur Verfügung steht.

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Authors and Affiliations

  1. Abteilung Rechtsmedizin I (Allg. Gerichtl. Medizin) der Christian-Albrechts-Universität zu Kiel, Hospitalstraße 17–19, D-2300, Kiel, Bundesrepublik Deutschland

    M. Krämer & R. Poetzsch-Heffter

Authors
  1. M. Krämer
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  2. R. Poetzsch-Heffter
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Herrn Prof. Dr. med. O. Grüner zum 65. Geburtstag gewidmet

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Krämer, M., Poetzsch-Heffter, R. Immunhistochemischer Arzneimittelnachweis in Autopsiematerial. Z Rechtsmed 93, 147–150 (1984). https://doi.org/10.1007/BF00200444

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  • DOI: https://doi.org/10.1007/BF00200444

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