Summary
The highly tumorigenic A-10 adenocarcinoma caused progressive tumor growth and death of syngenic A/J mice, whereas cultured A-10 cells did not cause tumors in all mice. The mixture of in vivo-grown and cultured A-10 tumor cells resulted in either progressive tumor growth or tumor rejection, depending upon the relative proportion of the two cell types. Expression of cell-surface carbohydrates was quantitated using cell-microbead, lectin-induced agglutination. The immunogenic, cultured A-10 tumor possessed a marked increase in agglutinability, compared to the in vivo-grown tumor. The results are consistent with the concept that the immunogenic properties of murine adenocarcinoma are closely associated with properties of the cell-surface.
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Supported, in part, by a research contract from the National Cancer Institute, USA
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Killion, J.J. Reduced tumorigenicity of A-10 adenocarcinoma in the presence of immunogenic A-10 tumor cells. Cancer Immunol Immunother 3, 93–95 (1977). https://doi.org/10.1007/BF00200064
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DOI: https://doi.org/10.1007/BF00200064