Skip to main content
SpringerLink
Log in

Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is inhibited by both prostaglandin E2 and nordihydroguaiaretic acid, a lipoxygenase inhibitor

  • Original Articles
  • Published:
Cancer Immunology, Immunotherapy Aims and scope Submit manuscript

Summary

Indomethacin enhanced macrophage cytostasis against MOPC-315 tumor cells in vitro. The effect of indomethacin was inhibited by prostaglandin E2 and by the lipoxygenase inhibitor nordihydroguaiaretic acid. Prostaglandin E2 and nordihydroguaiaretic acid also inhibited indomethacin stimulation of macrophage thymidine incorporation. Indomethacin inhibited macrophage prostaglandin E2 formation and stimulated leukotriene B4 synthesis. Nordihydroguaiaretic acid inhibited leukotriene B4 production. Our data indicate that eicosanoids play a role in regulating macrophage cytostasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Docherty JC, Wilson TW (1987) Indomethacin increases the formation of lipoxygenase products in calcium ionophore-stimulated human neutrophils. Biochem Biophys Res Commun 2:534

    Google Scholar 

  2. Ham EA, Soderman DD, Zanetti MA, Dougherty HW, McCauley E, Keuhl FA (1983) Inhibition by prostaglandins of leukotriene B4 release from activated neutrophiles. Proc Natl Acad Sci USA 80:4349

    Google Scholar 

  3. Kunkel SL, Chensue SW, Phan SH (1986) Prostaglandins as endogenous mediators of interleukin 1 production. J Immunol 136:186

    Google Scholar 

  4. Lee KC, Wong M, McIntyre D (1981) Characterization of macrophage subpopulations responsive to activation by endotoxin and lymphokines. J Immunol 126:2474

    Google Scholar 

  5. Ophir R, Ben-Efraim S, Bonta IL (1987) Leukotriene D4 and indomethacin enhance additively the macrophage cytostatic activity in vitro towards MOPC-315 tumor cells. Int J Tissue React 9:189

    Google Scholar 

  6. Opitz HG, Niethammer D, Jackson RC, Lemke H, Huget R, Flad HD (1975) Biochemical characterization of a factor released by macrophages. Cell Immunol 18:70

    Google Scholar 

  7. Parnham MJ, Bittner C, Winkelmann J (1983) Chemiluminescence from mouse resident macrophages: characterization and modulation by arachidonic acid metabolites. Immunopharmacology 5:277

    Google Scholar 

  8. Rola-Pleszczynski M, Lemaire I (1985) Leukotrienes augment interleukin 1 production by human monocytes. J Immunol 135:3958

    Google Scholar 

  9. Rola-Pleszczynski M, Gagnon L, Rudzinska M, Borgeat P, Sirois P (1984) Human natural cytotoxic cell activity: enhancement by leukotrienes (LT A4, B4 and D4, but not by stereoisomers of LTB4 or HETES. Prostaglandins Leukotrienes Med 13:113

    Google Scholar 

  10. Schenkelaars EJ, Bonta IL (1986) Cyclooxygenase inhibitors promote the leukotriene C4-induced release of beta-glucuronidase from rat peritoneal macrophages: prostaglandin E2 suppresses. Int J Immunopharmacol 8:305

    Google Scholar 

  11. Yui S, Yamazaki M (1986) Induction of macrophage growth by lipids. J Immunol 136:1334

    Google Scholar 

Download references

Author information

Author notes

  1. Carin Pellens

    Present address: Daniel den Hoed Clinic, Groene Hilledijk 301, 3027 EA, Rotterdam, The Netherlands

Authors and Affiliations

  1. Department of Pharmacology, Medical Faculty, Erasmus University Rotterdam, P.O.B. 1738, 3000 DR, Rotterdam, The Netherlands

    Graham R. Elliott, Corne Tak, Carin Pellens & Iven L. Bonta

  2. Department of Human Microbiology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Shlomo Ben-Efraim

Authors
  1. Graham R. Elliott
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Corne Tak
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carin Pellens
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shlomo Ben-Efraim
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Iven L. Bonta
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Elliott, G.R., Tak, C., Pellens, C. et al. Indomethacin stimulation of macrophage cytostasis against MOPC-315 tumor cells is inhibited by both prostaglandin E2 and nordihydroguaiaretic acid, a lipoxygenase inhibitor. Cancer Immunol Immunother 27, 133–136 (1988). https://doi.org/10.1007/BF00200017

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00200017

Keywords

Search

Navigation