Skip to main content
SpringerLink
Log in

Antitumor activity of living or killed Brucella: Modification of the non-specific cytotoxic effector cells

  • Original Articles
  • Published:
Cancer Immunology, Immunotherapy Aims and scope Submit manuscript

Summary

At various times after injection of living or killed smooth (S) or rough (R) Brucella abortus mice received a graft of the semi-allogenic EL4 lymphoma and their survival was studied. In parallel, the NK activity of spleen and peritoneal cells, the level of serum interferon (IFN), and the cytotoxic activity of peritoneal macrophages were investigated. Protection against the lymphoma lasted longer after injection of R organisms than after S. The parallelism between the in vivo resistance to EL4 lymphoma and the augmentation of NK and macrophage activity was satisfactory with R but not with S. IFN production did not seem to be correlated with R antitumor activity. The antitumor effect of Brucella cannot therefore be simply explained on the basis of modification of the non-specific cytotoxic effector mechanisms.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Dazord L, Martin A, Amice J, le Garrec Y, Toujas L (1978) Resistance to a peritoneal lymphoma graft induced by heat-killed S or R Brucella abortus. The role of activated macrophages. Cancer Immunol Immunother 4:49

    Google Scholar 

  2. Dazord L, le Garrec Y, Bonnier M, Toujas L (1980) Increased resistance to tumor graft in mice infected by vaccinal strains of Brucella abortus. Recent Results Cancer Res 75:92

    Google Scholar 

  3. Fidler IJ, Barues Z, Fogles WE, Kirsh R, Bugeski P, Poste G (1982) Involvement of macrophages in the eradication of established metastases following intravenous injections of liposomes, containing macrophages activators. Cancer Res 42:496

    Google Scholar 

  4. Gerson JM (1980) Systemic and in situ natural killer activity in tumor-bearing mice and patients with cancer. In: Herberman RB (ed) Natural cell-mediated immunity against tumors. Academic Press New York, p 1047

    Google Scholar 

  5. Gidlund M, Orn A, Wigzell H, Senik A, Gresser I (1978) Enhanced NK cell activity in mice injected with interferon and interferon inducers. Nature 273:759

    Google Scholar 

  6. Herberman RB, Ortaldo JR (1981) Natural killer cells: Their role in defense against disease. Science 214:24

    Google Scholar 

  7. Holmberg LA, Springer TA, Ault KA (1981) Natural killer activity in the peritoneal exudates of mice infected with Listeria monocytogenes: characterization of the natural killer cells by using monoclonal rat anti-murine macrophage antibody (M1/70). J Immunol 127:1792

    Google Scholar 

  8. Jett JR, Mantovani A, Herberman RB (1980) Augmentation of human monocyte-mediated cytolysis by interferon. Cell Immunol 54:425

    Google Scholar 

  9. Julius MH, Simpson E, Herzenberg LA (1973) A rapid method for the isolation of functional thymus derived murine lymphocytes. Eur J Immunol 3:645

    Google Scholar 

  10. Karre K, Klein GO, Kiessling R, Roder JC (1980) In vitro NK activity and in vivo resistance to leukemia studies of beige, beige/nude and wild-type hosts on C57B1 background. Int J Cancer 26:789

    Google Scholar 

  11. Kiessling R, Wigzell H (1979) An analysis of the murine NK cell as to structure, function and biological relevance. Immunol Rev 44:165

    Google Scholar 

  12. Le Garrec Y (1973) Variation lisse-rugueuse chez Brucella abortus. Quelques aspects immunologiques et immunochimiques. Thèse Docteur en Pharmacie. Université Paris Sud

  13. Le Garrec Y, Sabolovic D, Toujas L, Guelfi J, Pilet C (1974) Activity of inactivated Brucella on murine tumors: prophylactic effect and combination with specific immunostimulation. Biomedicine 21:40

    Google Scholar 

  14. Lotzova E (1980) C. parvum-mediated suppression of the phenomenon of natural killing and its analysis. In: Herberman RB (ed) Natural cell-mediated immunity against tumors. Academic Press, New York, p 117

    Google Scholar 

  15. Ojo E, Haller O, Kimura A, Wigzell H (1978) An analysis of conditions allowing Corynebacterium parvum to cause either augmentation or inhibition of natural cytotoxicity against tumor cells in mice. Int J Cancer 21:444

    Google Scholar 

  16. Riesenfeld I, Orn A, Gidlurd M, Axberg L, Alm GV, Wigzell H (1980) Positive correlation between in vivo NK activity and in vivo resistance towards AKR lymphoma cells. Int J Cancer 25:403

    Google Scholar 

  17. Schultz RM, Papamatheakis JD, Chirigos MA (1977) Interferon an induce of macrophage activation by polyanions. Science 197:674

    Google Scholar 

  18. Toujas L, Sabolovic D, Dazord L, le Garrec Y, Toujas JP, Guelfi J, Pilet C (1972) The mechanism of immunostimulation induced by inactivated Brucella abortus. Rev Eur Clin Biol 17:267

    Google Scholar 

  19. Wolfe SA, Tracey DE, Henney CS (1976) Induction of natural killer cells by BCG. Nature 62:584

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centre Régional de Lutte contre le Cancer, Hopital Pontchaillou, F-35000, Rennes

    L. Dazord

  2. Laboratoire d'Immunothérapie expérimentale, Institut Pasteur, F-75015, Paris

    Y. le Garrec

  3. Institut de Cancérologie et d'Immunogénétique, Hôpital Paul Brousse, F-94800, Villejuif, France

    I. Florentin

Authors
  1. L. Dazord
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Y. le Garrec
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. Florentin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dazord, L., le Garrec, Y. & Florentin, I. Antitumor activity of living or killed Brucella: Modification of the non-specific cytotoxic effector cells. Cancer Immunol Immunother 15, 63–67 (1983). https://doi.org/10.1007/BF00199464

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00199464

Keywords

Search

Navigation