Summary
Infusion of normal recipient mice with suppressor T cells from donors bearing a progressive Meth A fibrosarcoma results in a diminished capacity of the recipients to generate concomitant and postexcision antitumor immunity. The passive transfer of suppressor cells which prevented the generation of immunity to the Meth A fibrosarcoma did not affect the capacity of the recipients to reject an allogeneic tumor. The data provides direct evidence in support of the hypothesis that suppressor T cells, generated at later stages of growth of Meth A fibrosarcoma, function to down-regulate an already acquired mechanism of concomitant immunity.
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References
Berendt MJ, North RJ (1980) T cell-mediated suppression of antitumor immunity. An explanation for progressive growth of an immunogenic tumor. J Exp Med 151:69
Bonventre PF, Nikol AD, Ball EJ, Michael JG, Bubel HC (1982) Development of protective immunity against bacterial and viral infections in tumor-bearing mice coincident with suppression of tumor immunity. J Reticuloendothel Soc 32:25
Bursuker I, North RJ (1984) Generation and decay of the immune response to a progressive fibrosarcoma. II. Failure to demonstrate postexcision immunity after the onset of T cell mediated suppression of immunity. J Exp Med 159:1312
Dye ES, North RJ (1981) T cell-mediated immunosuppression as an obstacle to adoptive immunotherapy of the P815 mastocytoma and its metastases. J Exp Med 154:1033
Dye ES, North RJ (1984) Specificity of the T cells that mediate and suppress adoptive immunotherapy of established tumors. J Leukocyte Biol 36:27
Gorelik E (1983) Concomitant immunity and resistance to a second tumor challenge. Adv Cancer Res 39:41
Ledbetter JA, Herzenberg KA (1979) Xenogeneic monolonal antibodies to mouse lymphoid differentiation antigens. Immunol Rev 47:63
Mills CD, North RJ (1983) Expression of passively transferred immunity against an established tumor depends on generation of cytolytic T cells in recipients: inhibition by suppressor T cells. J Exp Med 157:1448
North RJ (1982) Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells. J Exp Med 155:1063
North RJ (1984) γ-Irradiation facilitates the expression of adoptive immunity against established tumors by eliminating suppressor T cells. Cancer Immunol Immunother 16:175
North RJ, Bursuker I (1984) Generation and decay of the immune response to a progressive fibrosarcoma. I. Ly-1+2− suppressor T cells down-regulate the generation of Ly-1−2+ effector T cells. J Exp Med 159:1295
North RJ, Dye ES, Mills CD (1982) T cell-mediated negative regulation of concomitant antitumor immunity as an obstacle to adoptive immunotherapy of established tumors. In: Fefer F, Goldstein AL (eds) The potential role of T cell populations in cancer therapy. Raven Press, New York p 65
Prehn RT, Main JM (1957) Immunity to methylcholanthrene-induced sarcomas. J Natl Cancer Inst 18:769
Schatten S, Granstein RD, Drebin JA, Greene, MI (1984) Suppressor T cells and the immune response to tumors. CRC Crit Rev Immunol 4:335
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This work was supported by Grants CA-16642 and CA-17794 from the National Cancer Institute, Grant RR-05705 from the Division of Research Resources, NIH, and a grant from R. J. Reynolds Industries, Inc
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Bursuker, I., North, R.J. Suppression of generation of concomitant antitumor immunity by passively transferred suppressor T cells from tumor-bearing donors. Cancer Immunol Immunother 19, 215–218 (1985). https://doi.org/10.1007/BF00199229
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DOI: https://doi.org/10.1007/BF00199229