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Demonstration of cells bearing the OKT6 determinant in human tonsil and lymph node

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Summary

An immunoperoxidase study was carried out on human tonsil (15 specimens) and human lymph node (5 specimens) using OKT6, a monoclonal antibody which was raised against a determinant on immature thymocytes. OKT6-positive cells were identified in the crypt epithelium of all tonsils examined and in occasional clusters in the interfollicular areas of two lymph nodes. OKT6 has recently been shown to react with epidermal dendritic cells (Langerhans' cells). This study confirms that OKT6-reactive cells may be found outside the thymus. The pattern of staining obtained suggests that OKT6 reactivity belongs to a dendritic subpopulation. The significance of the finding in relation to physiology and pathology is discussed. These physiological findings may also be relevant to the immunotherapy of T-cell lymphomas.

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Authors and Affiliations

  1. Departments of Dermatology and Pathology, University of Oklahoma Health Sciences Center, 619 N.E. 13th Street, 73104, Oklahoma City, Oklahoma, USA

    Euan M. McMillan, Daniel B. Brubaker, Scott Peters, Ingrid Jackson, Kathy Beeman, Rose Wasik, Lloyd E. Stoneking & Donald R. Resler

Authors
  1. Euan M. McMillan
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  2. Daniel B. Brubaker
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  3. Scott Peters
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  4. Ingrid Jackson
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  5. Kathy Beeman
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  6. Rose Wasik
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  7. Lloyd E. Stoneking
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  8. Donald R. Resler
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McMillan, E.M., Brubaker, D.B., Peters, S. et al. Demonstration of cells bearing the OKT6 determinant in human tonsil and lymph node. Cancer Immunol Immunother 15, 221–226 (1983). https://doi.org/10.1007/BF00199169

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  • DOI: https://doi.org/10.1007/BF00199169

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