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Calcium transport proteins in the nonfailing and failing heart: gene expression and function

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Abstract

In heart failure alterations of intracellular Ca2+ handling are thought to be a major reason for impaired contraction and relaxation. Peak Ca2+ transients are reduced, resting Ca2+ levels elevated, and the time course of diastolic Ca2+ decline is markedly prolonged in failing hearts. The proteins of the sarcoplasmic reticulum and the sarcolemmal Na+/Ca2+ exchanger are the most important tools for Ca2+ homeostasis in the cardiomyocyte, and their molecular cloning has allowed prediction of structure/function analysis. The investigation of function and gene expression of these proteins in failing myocardium has been an area of intensive research in recent years in order to provide a more detailed understanding of the pathophysiology of heart failure. Quantitative changes in expression of the sarcoplasmic reticulum Ca2+-ATPase, the ryanodine receptor, and the Na+/Ca2+ exchanger with correlations to functional alterations have been reported both in experimental animal models and in the human failing heart. However, in human heart failure these findings are currently the subject of a lively discussion because observations have apparently been in part contradictory. This review discusses the proteins involved in myocardial Ca2+ handling and describes the current state of research on expressional and functional alterations and their potential implication in the pathomechanism of heart failure.

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Abbreviations

ANF :

Atrial natriuretic factor

PLN :

Phospholamban

RyR :

Ryanodine receptor

SR :

Sarcoplasmic reticulum

SERCA :

Sarco(endo)plasmic reticulum Ca2+-ATPase

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  1. INSERM Unité 153, Pavillon Rambuteau, Hôpital Pitié-Salpétrière, 47, Boulevard de l'Hôpital, F-75651, 13, Paris Cedex, France

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Wankerl, M., Schwartz, K. Calcium transport proteins in the nonfailing and failing heart: gene expression and function. J Mol Med 73, 487–496 (1995). https://doi.org/10.1007/BF00198900

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