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Complement dependent in vitro neutralization of Chlamydia trachomatis by a subspecies-specific monoclonal antibody

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Abstract

Three murine monoclonal antibodies which combined specifically with Chlamydia trachomatis strain HAR-13 (Serotype A) were characterized. All antibodies cross-reacted with subspecies-specific epitopes in previously undescribed patterns. One of the antibodies showed a complement-dependent partial neutralization of strain HAR-13 in vitro, whereas the remaining two antibodies did not neutralize under any experimental conditions tested. The significance of subspecies-specific antibodies in neutralizing chlamydial infectivity in vivo remains to be determined.

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Author notes

  1. R. B. Clark

    Present address: Creighton University School of Medicine, Department of Medical Microbiology, Creighton University, 68178, Omaha, NE, USA

  2. I. Nachamkin

    Present address: Department of Pathology and Laboratory Medicine, University of Pennsylvania, 19104, Philadelphia, PA, USA

Authors and Affiliations

  1. Department of Clinical Pathology, Medical College of Virginia, Box 597, 23298, Richmond, VA, USA

    D. P. Fedorko, R. B. Clark, I. Nachamkin & H. P. Dalton

Authors
  1. D. P. Fedorko
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  2. R. B. Clark
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  3. I. Nachamkin
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  4. H. P. Dalton
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Fedorko, D.P., Clark, R.B., Nachamkin, I. et al. Complement dependent in vitro neutralization of Chlamydia trachomatis by a subspecies-specific monoclonal antibody. Med Microbiol Immunol 176, 225–228 (1987). https://doi.org/10.1007/BF00196690

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  • DOI: https://doi.org/10.1007/BF00196690

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