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Identification of fast spurts of pyridine nucleotide oxidation evoked by light stimulation in the isolated perfused vertebrate retina

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Abstract

Transitory increases of ultraviolet transmission on stimulation with light were recorded simultaneously with electroretinogram on and off effects from isolated vertebrate retina. The spectral distribution of the optical light responses coincided with that of NADH reduction. The correlation of the optical, or respiratory, responses and the electrical responses were very close within a wide range of stimulus parameters, suggesting an interpretation in terms of supply and demand of energy with a tight coupling between the two kinds of evoked activity. Prerequisite to the response behaviour was the preservation of synaptic signal transmission from first- to higher-order retinal neurons.

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References

  1. Appell HJ, Nelson MT, Marcus MM, Läuger P (1986) Effects of the ATP, ADP and inorganic phosphate on the transport rate of the Na+,K+-pump. Biochim Biophys Acta 857:105–115

    Google Scholar 

  2. Cox DWG (1984) The relationship between brain energy state and neuronal function? In: Vizi ES, Magyar K (eds) Regulation of transmitter function: basic and clinical aspects. Elsevier, Amsterdam, pp 11–23

    Google Scholar 

  3. Glynn IM (1985) The Na+,K+ transporting adenosine triphosphatase. In: Martinosi AN (ed) The enzymes of biological membranes, vol 3. Plenum Press, New York, pp 35–114

    Google Scholar 

  4. Guidotti G (1979) Coupling of ion transport to enzyme activity. In: Schmitt FO, Worden FG (eds) The neurosciences fourth study program. MIT Press, pp 831–840

  5. Hawryshin CN, Beauchamp R (1985) Ultraviolet photosensitivity in goldfish, an independent retinal UV mechanism. Vision Res 25(1):11–20

    Google Scholar 

  6. Karowski CJ, Proenza LM (1980) Neurons, potassium and glia in proximal retina of Necturnus. J Gen Physiol 75:141–162

    Google Scholar 

  7. Linsenmeier RA (1986) Effects of light and darkness on oxygen distribution and consumption in the cat retina. J Gen Physiol 88:521–542

    Google Scholar 

  8. Sickel W (1965) Respiratory and electrical responses to light stimulation in the retina of the frog. Science 148:648–651

    Google Scholar 

  9. Sickel W (1972) Retinal metabolism in dark and light. In: Fuortes MGF (ed) Handbook of sensory physiology, vol VII/2. Springer, Berlin, Heidelberg, New York, pp 667–727

    Google Scholar 

  10. Sickel W (1972) Electrical and metabolic manifestations of receptor and higher order neuron activity in vertebrate retina. Adv Exp Med Biol 24:101–118

    Google Scholar 

  11. Somjen GG, Rosenthal M, Cordingley G, LaManna JC, Lothman E (1976) Potassium, neuroglia and oxidative metabolism in the central grey matter. Fed Proc 35:1266–1271

    Google Scholar 

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Walter, P., Sickel, W. Identification of fast spurts of pyridine nucleotide oxidation evoked by light stimulation in the isolated perfused vertebrate retina. Graefe's Arch Clin Exp Ophthalmol 232, 318–323 (1994). https://doi.org/10.1007/BF00194483

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  • DOI: https://doi.org/10.1007/BF00194483

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