Abstract
The influence of pretreatment with a three day course of ciprofloxacin (500 mg twice daily) on a single oral dose of ethanol (30 g) was investigated in 12 healthy male volunteers in a double blind placebo controlled study.
Pretreatment with ciprofloxacin was shown to have no significant effect on ethanol AUC (736 mg·l-1 h placebo; 734 mg·l-1 h ciprofloxacin), Cmax (466 mg·l-1 placebo; 483 mg·l-1 ciprofloxacin) tmax (0.6 h placebo; 0.5 h ciprofloxacin) or the elimination rate (134 mg·l-1 h-1 placebo; 133 mg·l-1 h-1 ciprofloxacin).
The effect of ciprofloxacin on ethanol pharmacodynamics was measured by the use of psychomotor tests, such as the critical flicker fusion threshold, choice reaction time, pursuit rotor, tapping rate, digit symbol substitution and digit span. Subjective feelings of concentration, vigilance and relaxation were also measured using visual analogue scales.
Pretreatment with ciprofloxacin was found to have no significant effect on any of these tests, compared to placebo.
Similar content being viewed by others
References
Allen S, Oswald I (1976) Anxiety and sleep after fosazepam. Br J Clin Pharmacol 3: 165–168
Blake MFJ (1971) Temperature and time of day. In: Colquhoun WP (ed) Biological rhythms and human performance. Academic Press, London, pp 109–148
Chin JH, Goldstein DB (1976) Drug tolerance in biomembranes: a spin label study of the effects of ethanol. Science 196: 684–685
Chin JH, Goldstein DB (1977) Effects of low concentration of ethanol on the fluidity of spin-labeled erythrocyte and brain membranes. Molecular Pharmacol 13: 435–441
Gerald MC (1981) Pharmacology: an introduction to drugs, 2nd edn. Prentice-Hall, Englwood Cliffs
Harris RA, Schroeder F (1981) Ethanol and the physical properties of brain membranes: fluorescence studies. Mol Pharmacol 20: 128–137
Kamali F, Thomas SHL, Edwards C (1993) The influence of steady-state ciprofloxacin on the pharmacokinetics and pharmacodynamics of a single dose of diazepam. Eur J Clin Pharmacol 44: 365–367
Monk TM (1982) The arousal model of time of day effects in human performance efficiency. Chronobiologia 9: 49–54
Payne JP, Foster DV, Hill DW, Wood DGL (1967) Observation on interpretation of blood alcohol levels derived from analysis of urine. Br Med J 3: 819–823
Schwartz J, Jauregui L, Lettieri J, Bachmann K (1988) Impact of ciprofloxacin on theophylline clearance and steady state concentrations in serum. Antimicrobial Agents Chemother 32: 75–77
Segev S, Rahavi M, Rubinstein E (1988) Quinolones, theophylline and diclofenac interactions with gammaaminobutyric acid receptor. Antimicrobial Agents Chemother 32: 1624–1626
Seppala T, Linnoila M, Mattila MJ (1979) Drugs, alcohol and driving. Drugs 17: 389–408
Staib AH, Harder S, Mieke S, Beer C, Stille W, Shah P (1987) Gyrase inhibitors impair caffeine metabolism in man. Methods Find Exp Clin Pharmacol 9: 193–198
Tan KKC, Allwood MC, Shawket S (1990) Effect of ciprofloxacin on the pharmacokinetics of antipyrine in healthy volunteers. J Clin Pharm Ther 15: 151–154
Tsuji A, Sato H, Kume Y, Tamai I, Okezaki E, Nagato O, Kato H (1988) Inhibitory effects of quinolone antibacterial agents on gamma aminobutyric acid binding to receptor sites in rat brain membranes. Antimicrobial Agents Chemother 32: 190–194
Unseld E, Zeigler G, Gemeinhart A, Janssen U, Klotz U (1990) Possible interaction of fluoroquinolones with the benzodiazepine-GABAA-receptor complex. Br J Clin Pharmacol 30: 63–70
Wijnands WJA, Vree TB, Herwaarden CLA van (1986) The influence of quinolone derivatives on theophylline clearance. Br J Clin Pharmacol 22: 677–683
Wingard LB, Brody TM, Larner J, Schwartz A (1991) Human pharmacologgy: molecular to clinical. Mosby Year Book, St. Louis, Missouri, USA, pp 434–443
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kamali, F. No influence of ciprofloxacin on ethanol disposition. Eur J Clin Pharmacol 47, 71–74 (1994). https://doi.org/10.1007/BF00193482
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00193482