Summary
The afferent and efferent connections of the prelunate visual association area V4 of macaque monkeys were investigated by means of the horseradish peroxidase (HRP) method. The specific thalamic afferents from the dorsolateral segment of the medial pulvinar and the lateral segment of the inferior pulvinar were topographically organized. A band of cells was labelled in the intralaminar nuclei (nucl. centr. med. and lat., reaching into LD and the most dorsal part of VL), and a few cells in the interlaminar layers of the lateral geniculate body. Other diencephalic afferents included the claustrum, the nucleus basalis Meynert and the pars compacta of the substantia nigra. Ipsilateral cortical areas which projected into V4 included area 18 (V2), the inferior parietal cortex, the anterior and posterior parts of the superior temporal sulcus, the frontal eye fields and the temporo-basal association cortex on the lateral half of the parahippocampal gyrus and around the occipito-temporal sulcus. In the contralateral cortex, discontinuous regions in areas V4 and V5 on the prelunate gyrus and some cells at the 17/18-border were labelled. All regions in which labelled cells were found and, in addition a restricted region in the dorsal cap of the head and the tail of the caudate nucleus showed fibre and terminal labelling. In addition mesencephalic afferents and efferents were identified but not investigated in detail. An attempt to estimate the quantitative contribution of the various afferent systems to the prelunate cortex was made by counting the labelled cells in the different areas. The afferent and efferent organization of the prelunate visual association area indicates that it is incorporated in a network of cortical and subcortical regions involved in various aspects of visual behavior.
Similar content being viewed by others
References
Benevento LA, Rezak M (1976) The cortical projections of the inferior pulvinar and adjacent lateral pulvinar in the rhesus monkey (Macaca mulatta): An autoradiographic study. Brain Res 108:1–24
Bruce JC, Goldberg ME (1984) Physiology of the frontal eye fields. TINS 7:436–441
Creutzfeldt OD (1983) Cortex Cerebri. Leistung, struktuelle und funktioneile Organisation der Hirnrinde. Springer, Berlin Heidelberg New York
Creutzfeldt OD (1985) Comparaitve aspects of representation in the visual system. Exp Brain Res [Suppl] 11:53–81
Creutzfeldt OD, Weber H, Tanaka M, Lee BB (1987) Neural representation of spectral and spatial stimulus aspects in foveal and parafoveal area 17 of the behaving monkey. Exp Brain Res 68:541–564
Creutzfeldt OD (1988) Extrageniculo-striate visual mechanisms: Compartmentalization of visual functions. In: Hicks TP, Benedek G (eds) Progress in Brain Research, Vol 75. Vision within Extrageniculo-Striate Systems. Elsevier, Amsterdam, pp 307–320
Desimone R, Schein SJ, Moran J, Ungerleider L (1985 a) Contour, color and shape analysis beyond the striate cortex. Vision Res 25:441–452
Desimone R, Schein SJ, Albright TD (1985b) Form, color and motion analysis in prestriate cortex of the macaque. Exp Brain Res [Suppl] 11:165–178
Doty RW (1983) Nongeniculate afferents to striate cortex in macaques. J Comp Neurol 218:159–173
Fischer B, Boch R (1981a) Selection of visual targets activates prelunate cortical cells in trained rhesus monkeys. Exp Brain Res 41:431–433
Fischer B, Boch R (1981b) Enhanced activation of neurons in prelunate cortex before visually guided saccades of trained monkeys. Exp Brain Res 44:129–137
Fries W (1981) The projection from the lateral geniculate nucleus to the prestriate cortex of the macaque monkey. Proc R Soc [Biol] 213:73–80
Gross CG, Rocha-Miranda CE, Bender DB (1972) Visual properties of neurons in inferotemporal cortex of the macaque. J Neuophysiol 35:96–111
Gross CG, Bender DB, Gersin GL (1979) Activity of inferior temporal neurons in behaving monkeys. Neuropsychologia 17:215–229
Haenny PE, Schiller PH (1988) State dependent activity in monkey visual cortex: 1. Single cell activity in V1 and V4 on visual tasks. Exp Brain Res 69:225–44
Hyvärinen J (1982) The Parietal Cortex of Monkey and Man. Springer, Berlin Heidelberg New York
Itaya SK, Van Hoesen G (1983) Retinal projections to the inferior and medial pulvinar nuclei in the Old-World monkey. Brain Res 269:223–230
Iwai E, Mishkin M (1969) Further evidence on the locus of the visual area in the temporal lobe of the monkey. Exp Neurol 25:585–594
Jones EG, Powell TPS (1970) An anatomical study of converging sensory pathways within the cerebral cortex of the monkey. Brain 93:793–820
Kuypers HGJM, Szwarcbart MK, Mishkin M, Rosvold HE (1965) Occipitotemporal corticocortical connections in the rhesus monkey. Exp Neurol 11:245–262
Li Chaoyi, Tanaka M, Creutzfeldt OD (1989) Attention and eye movement related activation of neurons in the dorsal prelunate gyrus (area DP). Brain Res 496:307–313
Lysakowski A, Standage GP, Benevento LA (1988) An investigation of collateral projections of the dorsal lateral geniculate nucleus and other subcortical structures to cortical areas V1 and V4 in the macaque monkey: a double label retrograde tracer study. Exp Brain Res 69:651–661
Maunsell JHR, Newsome WT (1987) Visual processing in monkey extrastriate cortex. Annu Rev Neurosci 10:363–401
Mesulam M-M (1978) Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: A non-carcinogenic blue reaction-product with superior sensitivity for visualizing neural afferents and efferents. J Histochem Cytochem 26:106–117
Mishkin M (1972) Cortical visual areas and their interactions. In: Karczmar AG, Eccles JC (eds) Brain and Human Behavior. Springer, Berlin
Mishkin M (1982) A memory system in the monkey. Phil Trans R Soc Lond [Biol] 298:85–95
Mizuno N, Itoh K, Uchida K, Uemura-Sumi M, Matsushima R (1982) A retino-pulvinar projection in the macaque monkey as visualized by use of anterograde transport of horseradish peroxidase. Neurosci Lett 30:199–203
Mizuno M, Takahashi O, Itoh K, Matsusuhima R (1983) Direct projections to the prestriate cortex from the retino-recipient zone of the inferior pulvinar in the macaque monkey. Neurosci Lett 43:155–160
Moran J, Desimone R (1985) Selective attention gates visual processing in the extrastriate cortex. Science 229:782–784
Mountcastle VB, Lynch JC, Georgopoulos A, Sakata H, Acuna C (1975) Posterior parietal association cortex of the monkey: Command functions for operations within extrapersonal space. J Neurophysiol 38:871–908
Mountcastle VB, Anderson RA, Motter BC (1981) The influence of attentive fixation upon the excitability of the light-sensitive neurons of the posterior parietal cortex. J Neurosci 1:1218–1235
Perret DI, Rolls ET, Caan W (1982) Visual neurones responsive to faces in the monkey temporal cortex. Exp Brain Res 47:329–342
Rolls ET, Judge SJ, Sanghera MK (1977) Activity of neuron in the inferotemporal cortex of alert monkey. Brain Res 130:229–238
Room P, Groenewegen HJ (1986) Connections of the parahippocampal cortex. I. Cortical afferents. J Comp Neurol 251:415–450
Tanaka M, Lee BB, Creutzfeldt OD (1983) Spectral tuning and contour representation in area 17 of the awake monkey. In: Mollon JP, Sharpe LT (eds) Colour Vision: Physiology and Psychophysics Academic Press, London, pp 269–276
Tanaka M, Weber H, Creutzfeldt OD (1986) Visual properties and spatial distribution of neurons in the visual association area of the prelunate gyrus of the awake monkey. Exp Brain Res 65:11–37
Ungerleider LG (1985) The corticocortical pathways for object recognition and spatial perception. Exp Brain Res [Suppl] 11:21–37
Van Essen DC (1985) Functional organization of primate visual cortex. In: Peters A, Jones EG (eds) Cerebral Cortex, Vol 3. Visual Cortex. Plenum Press, New York London
Van Hoesen GW, Yeterian EH, Lavizzo-Mourey R (1981) Widespread corticostriate projections from temporal cortex of the rhesus monkey. J Comp Neurol 199:205–219
Vidyasagar TR, Salzmann E, Creutzfeldt OD (1988) Unit activity in the hippocampus and temporobasal cortex related to attention and memory in the behaving monkey. Abstr Soc Neurosci 14:1105
Yukie M, Iwai E (1981) Direct projection from the dorsal lateral geniculate nucleus to the prestriate cortex in macaque monkeys. J Comp Neurol 201:81–97
Zeki SM (1970) Interhemispheric connections of prestriate cortex in monkey. Brain Res 19:63–75
Zeki SM (1973) Colour coding in rhesus monkey prestriate cortex. Brain Res 53:422–442
Zeki SM (1978) Uniformity and diversity of structure and function in rhesus monkey prestriate visual cortex. J Physiol (Lond) 277:273–290
Zeki SM, Shipp S (1988) The functional logic of cortical connections. Nature 335:311–317
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tanaka, M., nLindsley, E., Lausmann, S. et al. Afferent connections of the prelunate visual association cortex (areas V4 and DP). Anat Embryol 181, 19–30 (1990). https://doi.org/10.1007/BF00189724
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00189724