Summary
For the esterification of 2-(4-ethylphenoxy)propionic acid catalyzed by lipase MY (Candida rugosa) in isopropyl ether containing a suitable amount of water, the enantioselectivity for the reaction has become higher as the reaction temperature increasing. In contrast, the reverse trend of the temperature effect has been observed for lipase AY (Candida rugosa). A model for these temperature dependence has been proposed.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Chen, C.-S., Fujimoto, Y., Girdaukas, G., and Sih, C. J. (1982). J. Am. Chem. Soc. 104, 7294.
Chen, C.-S. and Sih, C. J. (1989). Angew. Chem., Int. Ed. Engl. 28, 695.
Fitzpatrick, P. A. and Klibanov, A. M. (1991).J. Am. Chem. Soc. 113, 3166.
Kitaguchi, H., Itoh, I., and Ono, M. (1990). Chemistry Lett. 1203.
Klibanov, A. M. (1989). Acc. Chem. Res. 23, 114.
Parida, S. and Dordick, J. S. J. Am. Chem. Soc. (1991). 113, 2253.
Ueji, S., Fujino, R., Okubo, N., Miyazawa, T., Kurita, S., Kitadani, S., and Muromatsu, A. Biotechnol. Lett. (1992). 14, 163.
Witiak, D. T., Ho, T. C.-L., Hackney, R. E., and Corner, W. E. (1968). J. Med. Chem. 11, 1086.
Zaks, A. and Klibanov, A. M. J. Biol. Chem. (1988). 263, 8017.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yasufuku, Y., Ueji, Si. Effect of temperature on lipase-catalyzed esterification in organic solvent. Biotechnol Lett 17, 1311–1316 (1995). https://doi.org/10.1007/BF00189216
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00189216