Summary
This experimental study reports the results of implantation of cartilaginous and periosteal tissues into growth plate defects in the tibiae of sheep. When no material was used, the defect rapidly filled with marrow-like tissue. When cartilage from the margin of the secondary centre of ossification was implanted, endochondral ossification continued and no shortening or deformity resulted. Implantation of periosteum with or without reconstructed peripheral tissues resulted in the formation of a bony bridge which led to a 32% inhibition of longitudinal growth and a 12° varus deformity in the absence of peripheral connective tissues. After reconstruction with these tissues, the inhibition of longitudinal growth was 47% with a 28° varus deformity. The chondroprogenitor cells in the implanted tissues cannot change phenotypic expression. Periosteum has a strong potential for bone formation after it has been implanted.
Résumé
L'excision d'une plaque de croissance partiellement fusionnée et son remplacement par interposition de différents tissus n'a permis de montrer ni re-formation ni réparation de la structure anatomique de cette zone. Dans cette étude expérimentale nous présentons les résultats de l'implantation de cartilage ou de périoste dans la perte de substance créée au niveau de la partie interne de la plaque de croissance tibiale sur un modèle animal ovin. Sans interposition la cavité est rapidement remplie par un tissu ayant quelques ressemblances avec la moëlle osseuse. Le cartilage, à la limite du centre secondaire d'ossification, continue le processus d'ossification enchondrale avec formation d'os nouveau; plus lentement cependant que dans la zone de croissance normale adjacente. Sans comblement, de même qu'après implantation de cartilage, il ne se produit ni raccourcissement, ni angulation du membre opéré. L'implantation de périoste, avec ou sans reconstruction des structures périphériques entraîne la formation d'un pont osseux notable. Il y a une inhibition de la croissance en longueur de 32% et une angulation en varus de 12° en l'absence de reconstruction des tissus périphériques. Il y a une inhibition de la croissance de 47% et une angulation de 28° dans l'éventualité inverse. Nous en concluons que les cellules chondroprogéniques du tissu implanté ne peuvent pas changer leur expression phénotypique. Le périoste a un potentiel remarquable pour induire la formation d'os nouveau après transposition.
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Wirth, T., Byers, S., Byard, R.W. et al. The implantation of cartilaginous and periosteal tissue into growth plate defects. International Orthopaedics 18, 220–228 (1994). https://doi.org/10.1007/BF00188326
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DOI: https://doi.org/10.1007/BF00188326