Osteoinductive characteristics of new osteoplastic materials based on demineralized bone matrix of xenogenic origin with high and controlled degree of purification were studied on the model of regeneration of critical-size cranial defects in rats using modern approaches, including histological analysis, evaluation of morphological parameters of the bone tissue obtained by micro-computed tomography, and estimation of bone tissue growth rate using in vivo fluorochrome label. Demineralized bone matrix and, to a much greater extent, its activated form containing modified recombinant growth factor rhBMP-2 with high content of the dimeric form exhibited osteoinductive activity.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 162, No. 8, pp. 242-246, August, 2016
An erratum to this article is available at http://dx.doi.org/10.1007/s10517-017-3693-2.
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Bartov, M.S., Gromov, A.V., Poponova, M.S. et al. Modern Approaches to Studies of New Osteogenic Biomaterials on the Model of Regeneration of Critical-Size Cranial Defects in Rats. Bull Exp Biol Med 162, 273–276 (2016). https://doi.org/10.1007/s10517-016-3593-x
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DOI: https://doi.org/10.1007/s10517-016-3593-x