Skip to main content
Log in

Silent myocardial ischemia in glaucoma and cataract patients

  • Clinical Investigations
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

• Background: Glaucoma and cataract are multifactorial diseases. They have been described to be associated with cardiovascular risk factors. • Methods: Twentyfour-hour ECG monitoring was done in 22 normal-tension glaucoma patients, 27 open-angle glaucoma patients, 25 cataract patients, and 20 normal controls. The frequency of silent myocardial ischemia (SMI) as well as that of ventricular extrasystoles (VES) was evaluated. • Results: At least one episode of significant asymptomatic ST-T segment depression occurred in 45% of the normal-tension glaucomas, in 25.9% of open-angle glaucomas, in 12% of cataract patients, and in 5% of normal controls. The frequency of VES was not significantly different among the groups. • Conclusions: Glaucoma, especially normal-tension glaucoma, is significantly associated with the occurrence of episodic asymptomatic myocardial ischemias. Cataract patients, however, had only a slightly, statistically not significantly increased frequency of both SMI and VES compared with normals.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Bethge KP (1982) Langzeit-Elektrokardiographie bei Gesunden und bei Patienten mit koronarer Herzerkrankung. Springer, Berlin Heidelberg New York

    Google Scholar 

  2. Chen TT, Hockwin O, Dobbs R (1988) Cataract and health status: a case-control study. Ophthalmic Res 20:l-9

    Google Scholar 

  3. Christen WG, Manson JE, Seddon JM (1992) A prospective study of cigarette smoking and risk of cataract in men. JAMA 268:989–993

    Google Scholar 

  4. Coffman JO, Cohen RA (1981) Vasospasm ubiquitous? N Engl J Med 304:780–782

    Google Scholar 

  5. Flammer J (1995) The role of ocular circulation in the pathogenesis of glaucomatous damage. In: Krieglstein GK (ed) Glaucoma update V. Kaden, Heidelberg, pp 81–86

    Google Scholar 

  6. Flammer J (1996) To what extent are vascular factors involved in the pathogenesis of glaucoma? In: Kaiser HJ, Flammer J, Hendrickson P (eds) Ocular blood-flow. Karger, Basel, pp 12–39

    Google Scholar 

  7. Gasser P, Flammer J (1991) Blood-cell velocity in the nailfold capillaries of patients with normal-tension or high-tension glaucoma and of healthy controls. Am J Ophthalmol 111:585–588

    Google Scholar 

  8. Graham SL, Drance SM, Wijsman K, Douglas GR, Mikelberg S (1995) Ambulatory blood-pressure monitoring in glaucoma. Ophthalmology 102:61–69

    Google Scholar 

  9. Italian-American Cataract Study Group (1994) Incidence and progression of cortical, nuclear, and posterior subcapsular cataracts. Am J Ophthalmol 118:623–631

    Google Scholar 

  10. Kaiser HJ, Flammer J, Burckhardt D (1993) Silent myocardial ischemia in glaucoma patients. Ophthalmology 207:6–8

    Google Scholar 

  11. Kaiser HJ, Flammer J, Graf T, Stümpfig D (1993) Systemic blood pressure in glaucoma patients. Graefe's Arch Clin Exp Ophthalmol 231: 677–680

    Google Scholar 

  12. Kaiser HJ, Flammer J, Wenk M, Lüscher T (1995) Endothelin-1 plasma levels in normal-tension glaucoma: abnormal response to postural changes. Graefe's Arch Clin Exp Ophthalmol 233:484–488

    Google Scholar 

  13. Klein BE, Klein R, Linton KLP, Franke T (1993) Cigarette smoking and lens opacities: the Beaver Dam Eye Study. Am J Prev Med 9:27–30

    Google Scholar 

  14. Klein BE, Klein R, Jensen S, Linton KL (1994) Hypertension and lens opacities from the Beavers Dam Eye Study. Am J Ophthalmol 119:640–646

    Google Scholar 

  15. Klein R, Klein BE, Jensen SC, Moss SE, Cruickshanks KJ (1994) The relation of socioeconomic factors to age-related cataract, maculopathy, and impaired vision. Ophthalmology 101: 1969–1979

    Google Scholar 

  16. Klein R, Klein BE, Moss SE (1995) Age-diseae and survival. The Beaver Dam Study. Arch Ophthalmol 113: 333–339

    Google Scholar 

  17. Lesiewska-Junk H (1994) Senile and presenile cataract. Acta Ophthalmol 72:602–605

    Google Scholar 

  18. Miller D, Waters DD, Warnica W, Szlachcic J, Kreeft J, Théroux P (1982) Is variant angina the coronary manifestation of a generalized vasospastic disorder? N Engl J Med 304:763–766

    Google Scholar 

  19. Mohan M, Sperduto RD, Angra SK (1989) India-US case-control study of age-related cataracts. Arch Ophthalmol 107:670–676

    Google Scholar 

  20. Moriya S, Sugiyama T, Shimizu K, Hamada J, Tokuoka S, Azuma I (1992) Low-tension glaucoma and endothelium (ET-1). Folia Ophthalmol Jpn 43:554–559

    Google Scholar 

  21. Munoz B, Tajchman U, Bochow T, West S (1993) Alcohol use and risk of posterior subcapsular opacities. Arch Ophthalmol 111:110–112

    Google Scholar 

  22. Nasemann JE (1992) Die Fluoreszenz-Perfusions-Szintigraphie — eine neue Methode zur Quantifizierung okulärer Durchblutungsstörungen. Habilitationsschrift, University of Munich

  23. Orgül S, Flammer J (1995) Perilimbal aneurysms of conjunctival vessels in glaucoma patients. Ger J Ophthalmol 4:94–96

    Google Scholar 

  24. Orgül S, Flammer J, Gasser P (1995) Female preponderance in normal-tension glaucoma. Ann Ophthalmol 27:355–359

    Google Scholar 

  25. Peräsalo R, Perdsalo J, Raitta C (1992) Electrocardiographic changes in institutionalized geriatric glaucoma patients. Graefe's Arch Clin Exp Ophthalmol 230:213–217

    Google Scholar 

  26. Pillunat LE, Stodtmeister R (1988) Inzidenz des Niederdruckglaukoms bei hdmodynamisch relevanter Karotisstenose. Spektrum Augenheilkd 2: 24–27

    Google Scholar 

  27. Ringvold A, Blika S, Guldahl J, Brevik T, Hesstvedt P, Hoff K (1991) The middle-Norway eye-screening study. Acta Ophthalmol 69:273–280

    Google Scholar 

  28. Ritter LL, Klein BEK, Klein R, Mares-Perlman JA (1993) Alcohol use and lens opacities in the Beaver Dam Eye Study. Arch Ophthalmol 111: 113–117

    Google Scholar 

  29. Street DA, Javit JC (1992) National five-year mortality after in-patient cataract extraction. Am J Ophthalmol 113:263–268

    Google Scholar 

  30. Stroman GA, Steward WC, Golnik KC, Curé JK, Olinger RE (1995) Magnetic resonance imaging in patients with low-tension glaucoma. Arch Ophthalmol 113:168–172

    Google Scholar 

  31. Susanna R, Basseto KL (1992) Hemorrhage of the optic disc and neurosensorial dysacusia. J Glaucoma 1:248–253

    Google Scholar 

  32. Tielsch JM, Katz J, Sommer A, Quigley HA, Javitt JC (1995) Hypertension, perfusion pressure, and primary open-angle glaucoma. Arch Ophthalmol 113:216–221

    Google Scholar 

  33. Unakar NJ, Johnson M (1994) Lenticular alterations in hypertensive rats. Exp Eye Res 59:645–652

    Google Scholar 

  34. West SK, Valmadrid CT (1995) Epidemiology of risk factors for age-related cataract. Surv Ophthalmol 39: 323–334

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Waldmann, E., Gasser, P., Dubler, B. et al. Silent myocardial ischemia in glaucoma and cataract patients. Graefe's Arch Clin Exp Ophthalmol 234, 595–598 (1996). https://doi.org/10.1007/BF00185290

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00185290

Keywords

Navigation