Summary
We carried out experiments in rabbits to determine whether treating nerve transplants with gradually increasing concentrations of ethanol, ether and ficin would inhibit the graft-host immune reaction to the allograft. After treatment with ethanol, the basal laminar scaffold of the Schwann cell remained intact and there was satisfactory axonal regeneration. The results after additional treatment with ether or ficin did not achieve such good results. Preservation of the basal lamina is considered to be the essential factor in allowing neural regeneration in these circumstances.
Résumé
Nous avons réalisé une expérimentation sur le lapin afin de déterminer s'il était possible de supprimer chez le receveur les réactions immunitaires aux allogreffes, ceci en traitant les transplantations nerveuses à l'aide de concentrations progresivement croissantes d'éthanol, d'éther et de ficine. Après traitement par l'éthanol l'échafaudage laminaire basal des gaines de Schwann reste intact et il se produit une repousse correcte des axones. Les résultats ne sont pas aussi bons après traitement par l'éther ou par la ficine. La préservation de la laminaire basale est donc le facteur essentiel qui permet, dans cette situation, la régénération nerveuse.
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Hirasawa, Y., Katsumi, Y., Tamai, K. et al. An experimental study of nerve regeneration through chemically treated allografts. International Orthopaedics 14, 85–90 (1990). https://doi.org/10.1007/BF00183371
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DOI: https://doi.org/10.1007/BF00183371