Summary
Between June 1980 and June 1988, 373 patients with Wilms' tumors were diagnosed and treated (34.5%, stage I; 34.5%, stage II; 14.8%, stage III; 10.7%, stage IV; and 5.4%, stage V). In all, 11% of the patients were diagnosed as a result of routine checkup examinations. The tumor volume was <400 ml in 47.3% of cases and >400 ml in 52.7%. Overall, 78.7% of the patients had a standard-type Wilms' tumor, 7% had a low-grade malignancy lesion and 14.3% had a high-grade-malignancy tumor. Aside from radical tumor nephrectomy, treatment encompassed chemotherapy in all cases and radiotherapy in half of the patients according to the study protocol. In all, 32% of the children received preoperative treatment and 68% underwent primary surgery. Overall, 81.8% (305/373) of the patients were disease-free according to the probability of disease-free survival after 6 years as calculated using the Kaplan-Meier method, with 90% of the protocol group (196/218) being free of disease. After primary surgery and subsequent chemotherapy, 97.3% of the children with standard-type Wilms' tumors of stage I were cured and 94% of those with stage II tumors survived disease-free, as did 88% of those in stage III, 46% of those in stage IV, and 75% of those in stage V (Kaplan-Meier method). Radiotherapy was performed in 113 of the 218 protocol patients. Children demonstrating a clear-cell histology subtype did not show the poor prognosis attributed to this histology in the literature. Of the children with low-grade variants, 19 of 24 are free of disease. About 70% of all children with Wilms' tumor in the Federal Republic of Germany were entered in this study (47 of probably 68 new cases recorded annually nationwide×8 years). Of the 47 patients evaluated per year, 38 survived disease-free, whereas 9 per year either suffered from a disease or perished. The overall results are very satisfying. Additional treatment modifications can be achieved only through further studies. Not only for this reason is it recommended that Wilms' tumors be treated at large institutions. Wilms' tumor is the most common solid childhood tumor; 6.5% of all malignancies occurring in children are nephroblastomas. About 70 new cases are diagnosed every year in the Federal Republic of Germany.
The therapy of Wilms' tumors depends on various factors such as the clinical stage and histologic subtype of the tumor and the age of the patient. New information for optimization of the therapy can only be gathered by means of a nationwide study. We report on the clinical data and treatment results of 373 children. The aim of this study was to elucidate the relationship between the prognosis and the clinical stage and histologic subtype of the tumor as well as the age of the patients. In addition, the importance of pre- and/or postoperative radiotherapy was studied. Furthermore, the dose and duration of treatment with chemotherapeutic agents was evaluated.
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References
Asch MJ, Siegel S, White L, Fonkalsrud E, Hays D, Isaacs H (1985) Prognostic factors and outcome in bilateral Wilms' tumour. Cancer 56:2524–2529
Babaian RJ, Skinner DG, Waisman J (1980) Wilms' tumour in the adult patient. Diagnosis, management, and review of the world medical literature. Cancer 45:1713–1719
Beckwith JB (1986) Wilms' tumor and other renal tumors of childhood: an update. J Urol 136:320–324
Beckwith JB, Palmer NF (1978) Histopathology and prognosis of Wilms' tumour — results of the first National Wilms' Tumour Study. Cancer 41:1937–1948
Beckwith JB, Wang CI, Donnell GN et al. (1964) Hyperplastic fetal visceromegaly with macroglossia, omphalocele, cytomegaly of fetal adrenal cortex and other abnormalities. J Pediatr 65:1053
Belasco J, D'Angio GJ (1981) Wilms' tumour. Cancer 31:258–270
Belt TG, Cohen MD, Smith JA, Cory DA, McKenna S, Weetman R (1986) MRI of Wilms' tumour: promise as the primary imaging method. AJR 146:955–961
Bolande RP, Brough AJ, Izant RJ Jr (1967) Congenital mesoblastic nephroma of infancy. A report of eight cases and the relationship to Wilms' tumour. Pediatrics 40:272–278
Bracken RB, Sutow WW, Jaffe N, Ayala A, Guarda L (1982) Preoperative chemotherapy for Wilms' tumour. Urology 19:55–60
Breslow NE, Beckwith JB (1982) Epidemiological features of Wilms' tumour: results of the National Wilms' Tumour Study. J Natl Cancer Inst 68:429–436
Byrd RL, Evans AE, D'Angio GJ (1982) Adult Wilms' tumour: effect of combined therapy on survival. J Urol 127:648–651
Chadarévian J-P de, Vekemans M, Bernstein M (1985) Fanconi's anemia, medulloblastoma, Wilms' tumour, horseshoe kidney, and gonadal dysgenesis. Arch Pathol Lab Med 109:367–369
Clouse JW, Thomas PRM, Griffith RC, Perez CA, Vietti TJ, Fineberg B (1985) The changing management of Wilms' tumour over a 30-year period 1949–1978. Cancer 56:1484–1489
D'Angio GJ, Evans AE, Breslow N et al. (1976) The treatment of Wilms' tumour — results of the National Wilms' Tumour Study. Cancer 38:633–646
D'Angio GJ, Evans A, Breslow N et al. (1981) The treatment of Wilms' tumour: results of the second National Wilms' Tumour Study. Cancer 47:2302–2311
D'Angio GJ, Breslow N, Beckwith JB et al. (1989) The treatment of Wilms' tumour: results of the third National Wilms' Tumour Study. Cancer 64:349–360
Emblem R, Oppedal BR, Glomstein A, Kolbenstvedt A, Flatmark A (1985) Adult Wilms' tumour. Scand J Urol Nephrol 19:305–308
Green DM (1985) The diagnosis and management of Wilms' tumour. Pediatr Clin North Am 32:735–753
Green DM, Jaffe N (1978) Wilms' tumour — model of a curable pediatric malignant solid tumour. Cancer Treat Rev 5:143–172
Gutjahr P (1981) Wilmstumoren — eine Standortbestimmung. In: Hertl M, Kornhuber B, Landbeck G (Hrsg) Ergebnisse der Pädiatrischen Onkologie. Enke, Stuttgart, S 119–135
Gutjahr P (1987) Wilstumor (Nephroblastom). In: Gutjahr P (Hrsg) Krebs bei Kindern und Jugendlichen — Klinik und Praxis der pädiatrischen Onkologie. Deutscher Ärzteverlag, Köln, S 160–178
Gutjahr P, Daum R (1985) Wilms-Tumor (Nephroblastom). Dtsch Ärztebl 82:3358–3364
Harms D, Gutjahr P, Hohenfellner R, Willke E (1980) Fetal rhabdomyomatous nephroblastoma. Eur J Pediatr 133:167–172
Heideman RL, McGavran LL, Waldstein G (1986) Nephroblastomatosis and deletion of 11p. Am J Pediatr Hematol Oncol 8:231–234
Jones B, Breslow NE, Takashima J (1984) Toxic deaths in the second National Wilms' Tumour Study. J Clin Oncol 2:1028–1033
Jereb B, Eklund G (1973) Factors influencing the cure rate in nephroblastoma. A review of 335 cases. Acta Radiol [Oncol] 12:84–106
Jereb B, Tournade MF, Lemerle J et al. (1980) Lymph node invasion and prognosis in nephroblastoma. Cancer 45:1632–1639
Keating MA, D'Angio GJ (1988) Wilms' tumour update: current issues in management. Dialog Pediatr Urol 11:1–8
Lemerle J, Tournade M-F, Gerard-Marchant R et al. (1976) Wilms' tumour: natural history and prognostic factors. A retrospective study of 248 cases treated at the Institute Gustav-Roussy 1952–1967. Cancer 37:2557–2566
Lemerle J, Voute PA, Tournade MFT et al. (1976) Preoperative versus postoperative radiotherapy, single versus multiple courses of actinomycin D in the treatment of Wilms' tumour. Cancer 38:647–654
Lemerle J, Voute PA, Tournade M et al. (1983) Effectiveness of preoperative chemotherapy in Wilms' tumour: results of an International Society of Paediatric Oncology (SIOP) clinical trial. J Clin Oncol 1:604–609
Li FP, Gimbrere K, Gelber RD et al. (1987) Outcome of pregnancy in survivors of Wilms' tumour. JAMA 257:216–219
Marsden HB, Lawler W (1980) Bone metastasizing renal tumour of childhood. Histopathological and clinical review of 38 cases. Virchows Arch [A] 387:341–348
Matsunaga E (1981) Genetics of Wilms' tumour. Hum Genet 57:231–246
Maurer H (1986) Wilms' tumour follow-up. JAMA 255:2668–2678
Mesrobian HHJ (1988) Wilms' tumour: past, present, future. J Urol 140:231–238
Miller RW, Fraumeni JF Jr, Manning MD (1964) Association of Wilms' tumour with aniridia, hemihypertrophy and other congenital malformations. N Engl J Med 270:922–927
Pendergrass TW (1976) Congenital anomalies in children with Wilms' tumour, a new survey. Cancer 37:403–408
Penn I (1979) Renal transplantation for Wilms' tumour: report of 20 cases. J Urol 122:793–794
Pinkerton CR, Rogers H, James C, Bowman A, Barbor PRH, Eden OB, Pritchard J (1985) A phase II study of ifosfamide in children with recurrent solid tumours. Cancer Chemother Pharmacol 15:258–262
Riccardi VM, Sujanski E, Smith AC, Francke U (1978) Chromosomal imbalance in the aniridia-Wilms' tumour association: 11 p interstitial deletion. Pediatrics 61:604–610
Sandstedt B, Delemarre JFM, Krul EJ, Tournade MF (1985) Mesoblastic nephromas: a study of 29 tumours from the SIOP nephroblastoma file. Histopathology 9:741–749
Schmidt D, Harms D (1983) Histologie und Prognose des Nephroblastoms unter Berücksichtigung der Sondervarianten. Klin Pädiatr 195:214–221
Soulie J, Rousseau-Merck M-F, Mouly H, Nezelof C (1985) Bilateral nephroblastoma, associated with a 3:17 translocation. Cytogenet Cell Genet 39:64–66
Sutow WW, Breslow NE, Palmer NF, D'Angio GJ, Takahima J (1982) Prognosis in children with Wilms' tumour metastases prior to or following primary treatment. Results of the first National Wilms' Tumor Study (NWTS-1). Am J Clin Oncol 5:339–347
Tebbi K, Gross S (1978) Wilms' tumour in a mother and child. J Pediatr 92:1026–1027
Verga G, Parigi GB (1986) Partial nephrectomy for Wilms' tumour. J Urol 135:981–982
Wasiljew BK, Besser A, Raffensperger J (1982) Treatment of bilateral Wilms' tumour — a 22 year experience. J Pediatr Surg 17:265–268
Wigger HJ (1976) Fetal rhabdomyomatous nephroblastoma. A variant of Wilms' tumour. Hum Pathol 7:613–623
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Wammack, R., Fisch, M., Spaar, H.J. et al. Wilms' tumor — treatment and prognosis of 373 children. World J Urol 10, 100–106 (1992). https://doi.org/10.1007/BF00183143
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DOI: https://doi.org/10.1007/BF00183143