Abstract
In an attempt to resolve the question of the relative contributions of hydrodynamic pressure and infection to the pathogenesis of reflux nephropathy, we studied the pathologic changes in 46 kidneys subjected to vesico-ureteral reflux and obtained at necropsy from 36 patients, all aged less than 4 days. No scarring was seen in any of the kidneys, but 11 were hypoplastic and 4 were partly or completely dysplastic. This study supports the view that the pathologic features of reflux nephropathy are due to postnatal infection rather than to the hydrodynamic effect of reflux.
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Cussen, L.J., MacMahon, R.A. Perinatal renal changes associated with vesico-ureteral reflux. Pediatr Surg Int 10, 354–355 (1995). https://doi.org/10.1007/BF00182222
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DOI: https://doi.org/10.1007/BF00182222