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Lazaroids inhibit proliferation of cultured human astrocytoma cells

  • Laboratory Investigation
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Summary

Lazaroids (or 21-aminosteroids) are potent lipid peroxidation inhibitors and are more potent antioxidants than steroids which have been shown to suppress tumor proliferation. The effects of two lazaroid compounds (U-75389G and U-83836E) were tested on the proliferation of a human brain astrocytoma cell line U-373 MG. Both lazaroids had dose-dependent growth-inhibitory effects on the proliferation of U-373 MG. For purposes of comparison, two steroids (methylprednisolone and dexamethasone) and a highly potent antioxidant (alpha-tocopherol) were tested under similar experimental conditions and were found to have antiproliferative effects as well, although at higher dose ranges. As cell growth-inhibitors, lazaroids are more effective than alpha-tocopherol while they are advantageous over glucocorticoids for their actions are devoid of the usual glucocorticoid side-effects.

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Authors and Affiliations

  1. Neuroscience Program and Departments of Neurological Surgery and Physiology, Loyola University Medical Center, 2160 S. First Ave, 60153, Maywood, IL, USA

    Poonam Arora, Yong Soo Lee, Thomas C. Origitano & Robert D. Wurster

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  1. Poonam Arora
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  2. Yong Soo Lee
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  3. Thomas C. Origitano
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  4. Robert D. Wurster
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Arora, P., Lee, Y.S., Origitano, T.C. et al. Lazaroids inhibit proliferation of cultured human astrocytoma cells. J Neuro-Oncol 29, 143–148 (1996). https://doi.org/10.1007/BF00182137

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