Abstract
Two procedures to increase mucosal surface area in patients with short bowel syndrome have been evaluated in pigs. The colonic serosal patch technique of Binnington, Gaton, and Thompson for growth of new small-bowel mucosa revealed little if any neomucosal growth along the colonic serosal surface. Similarly, using the colonic muscle patch technique of Norton, Nothiger, and Watson no neomucosal growth was obtained along the vascularized, mucosally denuded colonic muscle surface. No mucosal growth was obtained even when the colonic serosa and the mucosally denuded colonic muscle were grafted with multiple free small-bowel mucosal grafts of 4–10 mm diameter. Removal of the colonic mucosa along the natural submucosal plane always left a vascularized colonic muscle that was histologically free of any colonic mucosal rests. None of the mucosally denuded colonic muscle surfaces regrew any colonic mucosa, and healing occurred essentially by contracture. We conclude that present techniques for inducing growth of new small-bowel mucosa do not provide sufficient new tissue for useful clinical application.
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Bianchi, A., Lendon, M. & Ward, I.D. A reassessment of surgical techniques for neomucosal growth. Pediatr Surg Int 7, 41–46 (1992). https://doi.org/10.1007/BF00181001
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DOI: https://doi.org/10.1007/BF00181001