Abstract
The interaction of concurrently administered amphetamine (AMPH) and haloperidol (HAL) on behavior was examined. Rats were divided into four groups: drug naive controls; HAL-treated for 6 months; AMPH-treated for 1 month; and rats administered both continuous HAL for 6 months and concurrent AMPH treatment during the 2nd month of HAL administration. AMPH alone increased locomotor activity, and this effect was blocked by concurrent haloperidol administration; however, the AMPH-induced reduction of body weight was unaltered by concurrent haloperidol treatment. Oral behavior, monitored both by a human observer and a computerized system, was not significantly altered by HAL alone, or by AMPH alone, but increases in tremorous oral behavior appeared in the concurrent administration group 4 months after AMPH treatment was discontinued. These results could have implications for tardive dyskinesia.
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Levy, A.D., Ellison, G.D. Interaction between chronic amphetamine and neuroleptic treatments on oral behavior in rats. Psychopharmacology 93, 218–222 (1987). https://doi.org/10.1007/BF00179937
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DOI: https://doi.org/10.1007/BF00179937