Abstract
Breast milk and serum samples were obtained from six psychotic patients 3 days–10 months after delivery. Five of the women were given zuclopenthixol PO daily, and one was given zuclopenthixol decanoate IM every 2 weeks. Zuclopenthixol was estimated in breast milk and serum by high performance liquid chromotography. The zuclopenthixol levels in milk were found to be 29% of the serum levels on average. Based on the drug levels found in milk, the daily dose to a suckling infant was estimated to be 0.5–5 μg zuclopenthixol, corresponding to a dose of 0.01–0.1 mg to an adult. It is not likely that such a low dose would cause any effects or side effects in the infant unless infants are very different from adults concerning metabolism or sensitivity to the drug. The suckling infants included in this study were apparently not influenced by the intake of zuclopenthixol with the milk.
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Aaes-Jørgensen T (1980) Specific high performance liquid chromatographic method for estimation of the cis(Z)- and trans(E)-isomers of clopenthixol and a N-dealkyl metabolite. J Chromatogr 183:239–245
Aaes-Jørgensen T, Gravem A, Jørgensen A (1981) Serum levels of the isomers of clopenthixol in patients given cis(Z)-clopenthixol or cis(Z)/trans(E)-clopenthixol. Acta Psychiatr Scand 64:70–77
Aaes-Jørgensen T, Kirk L, Petersen E, Danneskiold-Samsøe P, Jørgensen A (1983) Serum concentrations of the isomers of clopenthixol and a metabolite in patients given cis(Z)-clopenthixol decanoate in Viscoleo. Psychopharmacology 81:68–72
Brixen-Rasmussen L, Halgrener J, Jørgensen A (1982) Amitriptyline and nortriptyline Excretion in human breast milk. Psychopharmacology 76:94–95
Kirk L, Jørgensen A (1980) Concentrations of Cis(Z)-flupentixol in maternal serum, amniotic fluid, umbilical cord serum, and milk. Psychopharmacology 72:107–108
Matheson I, Evang A, Fredricson Overø K, Syversen G (1984) Presence of chlorprothixene and its metabolites in breast milk. Eur J Clin Pharmacol 27:611–613
Whalley LJ, Blain PG, Prime JK (1981) Haloperidol secreted in breast milk. Br Med J 282:1746–1747
Wiles DH, Orr MW, Kolakowska R (1978) Chlorpromazine levels in plasma and milk of nursing mothers. Br J Clin Pharmacol 5:272–273
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Aaes-Jørgensen, T., Bjørndal, F. & Bartels, U. Zuclopenthixol levels in serum and breast milk. Psychopharmacology 90, 417–418 (1986). https://doi.org/10.1007/BF00179202
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DOI: https://doi.org/10.1007/BF00179202