Abstract
Shaking movements, similar to those made by a dog when wet, were elicited in rats by a) immersion in ice-water, b) injections of icilin, a chemical that produces sensations of cold, and c) naloxone-precipitated morphine withdrawal. Adenosine and 2-chloroadenosine produced dose-dependent inhibition of shaking to ice-water and icilin. The 2-chloroadenosine effect was mediated centrally because the ICV dose required to produce inhibition was not effective when given IP. Caffeine antagonized the inhibitory effects of adenosine and 2-chloroadenosine. 2-Chloroadenosine suppressed morphine-abstinence shaking as well as the body weight loss that normally accompanies withdrawal.
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Tse, S.Y.H., Wei, E.T. Inhibition of the shake response in rats by adenosine and 2-chloroadenosine. Psychopharmacology 90, 322–326 (1986). https://doi.org/10.1007/BF00179184
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DOI: https://doi.org/10.1007/BF00179184