Summary
This study was undertaken to examine the fate of articular cartilage in isogenic half-joint grafts implanted after storage by two-stage freezing. The antigenicity was evaluated quantitatively with regard to humoral and cellular immunological responses: none was seen in allogenic cartilage grafts. In the half-joint transplantations, the antigenicity of the cartilage need not be considered; only the antigenicity of cortical and cancellous bone must be reduced. Histologically, half-joint grafts stored at −196°C were superior to fresh allografts. Two-stage freezing, therefore, appears to be useful for the storage of articular cartilage.
Résumé
Cette étude a été entreprise afin de préciser le devenir du cartilage articulaire dans les greffes d'une hémi-articulation implantées après conservation par congélation en deux temps. L'antigènicité a été évaluée quantitativement d'après les réponses immunologiques humorale et cellulaire: il n'en a pas été noté dans les greffes de cartilage allogène. Dans les transplantations hémi-articulaires, il n'y a pas lieu de se préoccuper de l'antigènicité du cartilage, seule celle de l'os, cortical et spongieux, doit être diminuée. Histologiquement, les greffes hémiarticulaires conservées à −196° sont supérieures aux allogreffes fraiches. La congélation en deux temps semble donc utilisable pour la conservation du cartilage articulaire.
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Okada, Y., Sakakida, K., Fujita, T. et al. Experimental studies on half-joint transplantation. International Orthopaedics 14, 261–267 (1990). https://doi.org/10.1007/BF00178756
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DOI: https://doi.org/10.1007/BF00178756