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Misonidazole neurotoxicity in rats: Part 11

Effect of pre- and intermittent treatment with pentobarbital on misonidazole neurotoxicity in the rat

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Summary

Rats pretreated for 5 days with 50 mg/ kg of pentobarbital tolerated statistically significant higher doses of misonidazole before the onset of misonidazole-induced neurotoxicity than rats treated intermittently with the same dose of pentobarbital. Presumably in pretreated rats, pentobarbital induced an increase in the activities of hepatic microsomal enzymes that led to a more rapid metabolism of misonidazole than in rats treated only intermittently.

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Authors and Affiliations

  1. Brain Tumor Research Center of the Department of Neurological Surgery, School of Medicine, University of California, 94143, San Francisco, CA, USA

    Michael SB Edwards, Deborah G Gordon, Alan Salamy, Victor A Levin & Theodore L Phillips

  2. Department of Radiation Oncology, School of Medicine, University of California, 94143, San Francisco, CA, USA

    Michael SB Edwards, Deborah G Gordon, Alan Salamy, Victor A Levin & Theodore L Phillips

Authors
  1. Michael SB Edwards
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  2. Deborah G Gordon
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  3. Alan Salamy
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  4. Victor A Levin
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  5. Theodore L Phillips
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Edwards, M.S., Gordon, D.G., Salamy, A. et al. Misonidazole neurotoxicity in rats: Part 11. J Neuro-Oncol 2, 95–98 (1984). https://doi.org/10.1007/BF00177892

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  • DOI: https://doi.org/10.1007/BF00177892

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