Abstract
Recent studies have shown that technetium 99m mercaptoacetyltriglycine (MAG-3) is a suitable replacement for iodine 131 or 123 hippurate in gammacamera renography. Also, the determination of its clearance is of value, since it correlates well with that of hippurate and thus may be an indirect measure of renal plasma flow. In order to simplify the clearance method we developed formulas for the estimation of plasma clearance of MAG-3 based on a single plasma sample and compared them with the multiple sample method based on 7 plasma samples. The correlation to effective renal plasma flow (ERPF) (according to Tauxe's method, using iodine 123 hippurate), which ranged from 75 to 654 ml/min per 1.73 m2, was determined in these patients. Using the developed regression equations the error of estimate for the simplified clearance method was acceptably low (18–14 ml/min), when the single plasma sample was taken 44–64 min post-injection. Formulas for different sampling times at 44, 48, 52, 56, 60 and 64 min are given, and we recommend 60 min as optimal, with an error of estimate of 15.5 ml/min. The correlation between the MAG-3 clearances and ERPF was high (r = 0.90). Since normal values for MAG-3 clearance are not yet available, transformation to estimated ERPF values by the regression equation (ERPF=1.86 × CMAG-3 + 4.6) could be of clinical value in order to compare it with the normal values for ERPF given in the literature.
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References
Bubeck B, Brandau W, Steinbaecher M (1988) Technetium-99m labeled renal functioning and imaging agents (1988). II. Clinical evaluation of 99mTc-MAG-3 (99mTc-mercapto-acetylglycylgly-cylglycine). Nucl Med Biol 15:109–118
Christensen AB, Groth S (1986) Determination of 99mTc-DTPA clearance by a single plasma sample method. Clin Physiol 6:579–588
Claessens RAMJ, Corstens FHM (1990) Tc-99m-MAG-3 clearance determined in patients by simplified methods. In: Schmidt HAE, Chambron J (eds) Nuclear medicine. Schattauer, Stuttgart, pp 432–434
Dubovsky EV, Russel CD (1982) Quantitation of renal function with glomerular and nuclear agents. Semin Nucl Med 12:308–329
Ensing GJ, Nielsen J, Panek-Finda H (1988) Development of a kit formulation for the labelling of mercaptoacetyl triglycine (MAG3) with 99mTc. Eur J Nucl Med 14:303
Fritzberg AR, Kasina S, Eshima D, Johnson DL (1986) Synthesis and biologic evaluation of technetium-99m-MAG3 as a hippuran replacement. J Nucl Med 27:111–116
Jafri AR, Britton KE, Nimmon CE (1988) Technetium-99-m-MAG3, a comparison with iodine-123 and iodine-131-orthoiodohippurate in patients with renal disorder. J Nucl Med 29:147–158
Martin WG, Wolf IH, Kempken K, PabstHW (1989) Tc 99m-MAG3 versus I-123 OIH; comparison of quantitative parameters in renal function. In: Schmidt HEA, Busaggi GL (eds) Nuclear medicine. Schattauer, Stuttgart, pp 413–416
Müller-Suur R, Müller-Suur C (1986) Renal and extrarenal handling of a new imaging compound (99m-Tc-MAG-3) in the rat. Eur J Nucl Med 12:438–442
Müller-Suur R, Müller-Suur C (1989) Glomerular filtration and tubular secretion of MAG-3 in the rat kidney. J Nucl Med 30:1986–1991
Müller-Suur R, Bois-Svensson I, Mesko L (1990) A comparative study of renal scintigraphy and clearance with Tc-99m-MAG-3 and 123-I-hippurate in patients with renal disorders. J Nucl Med 31:1811–1817
Russel CD, Thorstad BL, Yester MV (1988) Quantitation of renal function with technetium-99m-MAG-3. J Nucl Med 29:1931–1933
Russel CD, Taylor A, Eshima D (1989) Estimation of technetium-99m-MAG-3 plasma clearance in adults from one or two blood samples. J Nucl Med 30:1955–1959
Sapirstein LA, Vidt DG, Mandel MJ, Hanuselx G (1955) Volumes of distribution and clearances of intravenously injected creatinine in the dog. Am J Physiol 181:330–336
Tauxe WN (1985) Tubular function. In: Tauxe WN, Dubovsky EV (eds) Nuclear medicine in clinical urology and nephrology. Appleton-Centring-Crofts, Norwalk, pp 77–105
Taylor A, Ziffer JA, Stevens A, Eshima D, Delaney VB, Weekel JD (1989) Clinical comparison of I-131 orthoiodohippurate and the kit formulation of Tc-99m-mercaptoacetyltriglycine. Radiology 170:721–725
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Müller-Suur, R., Magnusson, G., Bois-Svensson, I. et al. Estimation of technetium 99m mercaptoacetyltriglycine lasma clearance by use of one single plasma sample. Eur J Nucl Med 18, 28–31 (1991). https://doi.org/10.1007/BF00177681
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DOI: https://doi.org/10.1007/BF00177681