Abstract
The effects of single 10 mg oral doses of the antidepressant mianserin on psychomotor performance, subjective sedation and supine and standing blood pressure were compared in ten young and nine elderly healthy volunteers. Immediate and residual sedation following this subtherapeutic dose was readily detected in both groups. In contrast to previous studies with benzodiazepines, the sedation effect was not accentuated in the older subjects. Subjective awareness of sedation was significant in the young but not, however, in the elderly. “First-dose” postural hypotension, presumably due to post-synaptic alpha-blockade also occurred in young subjects only. Caution may be needed on initial dosage of mianserin in young individuals who drive or undertake skilled tasks and in the elderly who may be unaware of psychomotor impairment. The reported alpha2 receptor selectivity of mianserin might explain the lack of postural effects in the elderly, and might constitute a potentially useful characteristic in the development of new compounds.
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References
Bond A, Lader M (1974) The use of analogue scales in rating subjective feelings. Br J Med Psychol 47:211–218
Castleden CM, George CF, Marcer D, Hallett C (1977) Increased sensitivity to nitrazepam in old age. Br Med J 1:10–12
Cook PJ, Flanagan R, James IM (1984) Diazepam tolerance: effect of age, regular sedation, and alcohol. Br Med J 289:351–353
Docherty JR, Hyland L (1985) Evidence for neuro-effective transmission through post-junctional alpha 2-adrenoceptors in human saphenous vein. Br J Pharmacol 84:573–576
Elliot HL, Whiting B, Reid L (1983) Assessment of the interaction between mianserin and centrally-acting hypertensive drugs. Br J Clin Pharmacol 15:323S–328S
Fagan D, Jostell K, Mitchell R, Lamont M, Tiplady B, Scott DB (1986) Psychometric effects of chlormethiazole in healthy young and elderly subjects. In: Abstracts, British Association for Psychopharmacology Meeting, Cambridge, July 9186
Gribbin B, Pickering TG, Sleight R, Peto R (1971) Effect of age and high blood pressure on baroreflex sensitivity in man. Circ Res 29:424–431
Hart J, Hill HM, Bye CE, Wilkinson RT, Peck AW (1976) The effects of low doses of amylobarbitone sodium and diazepam on human performance. Br J Clin Pharmacol 3:289–298
Hindmarch I (1975) A 1,4-benzodiazepine, temazepam (K3917), its effect on some psychological parameters of sleep and behaviour. Arzneimittelforschung (Drug Res) 25:1836–1839
Hyland L, Docherty JR (1985) An investigation of age-related changes in pre- and post-junctional alpha-adrenoceptors in human saphenous vein. Eur J Pharmacol 114:361–364
Marshall RJ (1983) The pharmacology of mianserin — an update. Br J Clin Pharmacol 15:263S–268S
Mattila MJ, Liljequist R, Seppala T (1978) Effects of amitriptyline and mianserin on psychomotor skills and memory in man. Br J Clin Pharmacol 5:53S–55S
McGarry K, Laher MS, Horgan J, O'Brien ET, O'Malley K (1981) Baroflex function in elderly hypertensives. Br Heart J 45:620
McGrath JC (1982) Evidence of more than one type of postjunctional α-adrenoceptor. Biochem Pharmacol 31:467–484
Moller M, Thayssen P, Kragh-Sorensen P, Pedersen OL, Kristensen CB, Bjerre M, Benjaminsen S, Gram LF (1983) Mianserin: cardiovascular effects in elderly patients. Psychopharmacology 80:174–177
Pedigo NW, Shoemaker H, Morselli M (1981) Benzodiazepine receptor binding in young, mature and senescent rat brain and kidney. Neurobiol Aging 2:83–88
Scott DB, Fagan D, Tiplady B (1982) Effects of amitriptyline and zimelidine in combination with ethanol. Psychopharmacology 76:209–211
Swift CG (1982) Zimelidine in the elderly. Br J Clin Pract S19:92–97
Swift CG (1983) Studies on the response to benzodiazepines in the elderly. PhD Thesis, University of Dundee
Swift CG (1984) Postural instability as a measure of sedative drug response. Br J Clin Pharmacol 18:87S–90S
Swift CG, Tiplady B (1988) The effects of age on the response to caffeine. Psychopharmacology 94:29–31
Swift CG, Ewen JN, Clarke P, Stevenson IH (1985a) Responsiveness to oral diazepam in the elderly: relationship to total and free plasma concentrations. Br J Clin Pharmacol 20:111–118
Swift CG, Swift MR, Ankier SI, Pidgen A, Robinson J (1985b) Single dose pharmacokinetics and pharmacodynamics of oral loprazolam in the elderly. Br J Clin Pharmacol 20:119–128
Thompson P, Huppert FA, Trimble M (1981) Phenytoin and cognitive function. Br J Clin Psychol 20:155–162
Tiplady B (1985) An automated test battery for the detection of changes in mental function and psychomotor performance. Br J Clin Pharmacol 20:305P
Tiplady B (1988) A continuous attention test for the assessment of the acute behavioral effects of drugs. Psychopharmacol Bull (in press)
Tsang CC, Speed KV, Wilkinson GR (1982) Ageing and benzodiazepine binding in the rat cerebral cortex. Life Sci 30:343–346
Wright BM (1971) A simple mechanical ataxiameter. J Physiol 218:27P–28P
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Swift, C.G., Swift, M.R. & Tiplady, B. “First-dose” response to mianserin: effects of age. Psychopharmacology 96, 273–276 (1988). https://doi.org/10.1007/BF00177574
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DOI: https://doi.org/10.1007/BF00177574